Last updated on February 2018

High Definition Cathodal Transcranial Direct Current Stimulation for Treatment of Refractory Partial Onset Epilepsy

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Epilepsy
  • Age: Between 9 - 65 Years
  • Gender: Male or Female

Inclusion Criteria:

  1. Age 9 to 65 years
  2. Focal-onset neocortical epilepsy (as determined by semiology, EEG, and/or MRI)
  3. Frequent (>50% of EEG record) focal epileptiform discharges on EEG and/or frequent (defined as average of 2 daily seizures) focal-onset clinical seizure, refractory to medical anti-epileptic treatment. For the purposes of this study, any patient who has been treated with three or more AEDs at therapeutic doses for at least four weeks per drug will be considered medically refractory.
  4. Seizure onset must be localizable by clinical semiology, EEG or MRI.
  5. Subjects or guardians must be competent to sign an informed consent indicating awareness of the investigational nature of this study, treatment, benefits and procedures involved.

Exclusion Criteria:

  1. Age over 65 years or under 9 years.
  2. Implanted cardiac pacemakers, cochlear implants, implanted medication pump, or intracardiac line.
  3. Within past six months, history of active heart disease, stroke, respiratory disease, or increased intracranial pressure such as after infarction or trauma.
  4. Pregnant women. A urine test will be conducted on all post-menarchal females of childbearing age and potential to verify they are not pregnant.
  5. History of significant head trauma (loss of consciousness >10 minutes) within the past 6 months.
  6. Currently taking tricyclic anti-depressants, bupropion, or neuroleptic medications.
  7. Intracranial metal (e.g., cortical stimulator, deep brain stimulator, intraventricular catheter) within 4 cm of optimal stimulation site. Location of cranial metal (e.g. skull screws) should be carefully documented.
  8. Neurodegenerative disease.
  9. Radiographic or electrophysiologic evidence for deep structure seizure focus (e.g., mesial temporal sclerosis or periventricular heterotopia)
  10. Inability to remain seated and relatively still for 30 minutes.
  11. Benign rolandic epilepsy.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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