Use of Hyperpolarized Xenon Gas for Lung Imaging in Children and Adults

  • STATUS
    Recruiting
  • End date
    Aug 24, 2024
  • participants needed
    300
  • sponsor
    Children's Hospital Medical Center, Cincinnati
Updated on 27 January 2021
pulmonary function test

Summary

The goal of this study is to evaluate the usefulness of hyperpolarized (HP) 129Xe (xenon) gas MRI for regional assessment of lung function in a normal population of children and adults and in adults and also in children with respiratory compromise due to a variety of diseases.

Description

Hyperpolarized 129Xe will be produced, by trained staff, using a polarizer housed at Cincinnati Children's Hospital Medical Center. Individual imaging sessions will be done on a single day and will involve administration of (maximum) 1 liter doses (less for children) for up to four MRI scans. Subject will inhale hyperpolarized xenon gas and hold breath for up to 16 seconds during the MRI scans. In addition to 129 Xe MRI, a series of anatomical conventional proton MR images may also be collected. Follow up phone calls will be done one day and 30 days from the MRI date.

Details
Condition Respiratory disorder, respiratory disease, respiratory diseases, respiratory disorders, diseases of the respiratory system
Treatment Hyperpolarized 129 Xenon
Clinical Study IdentifierNCT02272049
SponsorChildren's Hospital Medical Center, Cincinnati
Last Modified on27 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

Ages 6 and up
Participant must be able to hold breath for up to 16 seconds

Exclusion Criteria

History of heart defect
Pregnancy or positive pregnancy test
History of uncontrolled asthma defined for this study as requiring use of rescue inhaler 2 times in past month
Symptoms of respiratory infection (loose or productive cough or wheeze), chest tightness, or sinus infection within past week
Baseline oximetry at MRI visit of less than 95% on room air or less than 95% on a previously prescribed dosage of oxygen delivered by nasal cannula
Participant is claustrophobic and unable to tolerate the imaging
Standard MRI exclusions (metal, implants)
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