Last updated on October 2018

Rizatriptan for Episodic Dizziness in Vestibular Migraine


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Vestibular Migraine | Migrainous Vertigo
  • Age: Between 18 - 65 Years
  • Gender: Male or Female

Inclusion Criteria: Must answer yes to be eligible

  1. Are between the ages of 18 & 65
  2. Have a history of vestibular migraine
  3. Are able to maintain a vestibular symptom diary

History that fulfills all criteria for VM as defined in Table 1, except that attacks must last at least 2 hours.

4. At least 5 episodes

5. A current or past history of migraine without aura or migraine with aura

6. Vestibular symptoms of moderate or severe intensity lasting at least 2 hours

7. 50% of episodes are associated with at least one of the following:

Headache with at least 2 of:

  • unilateral location
  • pulsating quality
  • moderate or severe intensity,
  • aggravation by routine physical activity 8. Experience photophobia and phonophobia 9. Experience visual aura 10. Episodes must have a spontaneous onset and resolution without associated hearing loss or interictal neurotologic deficits. 11. Other causes of vestibular symptoms ruled out by appropriate clinical investigations. 12. Current medication list compatible with Concomitant Medications below. 13. Able to maintain a Vestibular Symptom Diary and complete all other study procedures.

Exclusion Criteria: Must answer no to be eligible.

  1. Mnire's disease by The American Academy of Otolaryngology-Head and Neck Surgery Foundation (AAO-HNS) criteria60.
  2. Migraine with brainstem aura (formerly basilar-type migraine) by the International Classification of Headache Disorders (ICHD-3) criteria.14
  3. Ischemic heart disease, coronary artery vasospasm, uncontrolled hypertension.
  4. History of stroke or transient ischemic attack.
  5. History of using rizatriptan specifically to treat vestibular attacks.
  6. History of adverse response to triptans or intolerance to lactose.
  7. Women who are pregnant or breastfeeding.
  8. Unable or unwilling to comply with study requirements for any reason.

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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