Last updated on March 2019

Phase 2 Study to Examine Grape Seed Extract as an Anti-Oligomerization Agent in Alzheimer's Disease (AD)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Alzheimer's Disease
  • Age: - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • NINCDS/ADRDA criteria for probable AD
  • MMSE between 12-26
  • Treatment with a cholinesterase inhibitor or an NMDA (N-methyl-D-asparate) antagonist with stable dose for at least 12 weeks
  • Home monitoring available for supervision of medications
  • Caregiver available to accompany patient to all visits and willing to participate in study as informant
  • Fluent in English or Spanish
  • Medical stability for this study as confirmed by review of records, internist's physical exam, neurological exam, and laboratory tests
  • Stable doses of non-excluded medication
  • No evidence of hepatic insufficiency
  • Able to swallow oral medications
  • Ability to participate in the informed consent process

Exclusion Criteria:

  • History of hypotension or unstable hypertension
  • Active hepatic or renal disease
  • Use of another investigational drug within the past two months
  • History of clinically significant stroke
  • History of seizure or head trauma with disturbance of consciousness within the past two years
  • Major mental illness including psychotic disorders, bipolar disorder, or major depressive episode that is not in remission for less than 12 months
  • Women of child-bearing age unless using effective birth control or at least one year post-menopausal or surgically menopausal
  • Any ferrous or metallic materials which are contraindicated for MRI

Medication Exclusions

  • Current use of drugs with significant anticholinergic or antihistaminic properties

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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