Last updated on August 2013

Surgery in Treating Patients With Neuroblastoma

Brief description of study

RATIONALE: Surgery may be an effective treatment for neuroblastoma. PURPOSE: This phase II trial is studying how well surgery works in treating patients with neuroblastoma.

Detailed Study Description

OBJECTIVES: - Evaluate the safety and efficacy of surgical treatment alone for stage II neuroblastoma without N-myc amplification (NMA). - Describe predictive factors of relapse and survival for stages I and II neuroblastoma without NMA treated by surgery alone. OUTLINE: Patients with localized resectable tumors undergo surgery. Postoperative evaluations are performed 30 days following surgery. Study patients with stage I (without N-myc amplification) tumors and trial patients with stage II tumors receive no further therapy. Study patients (except stage I patients) receive surgery and/or chemotherapy according to other protocols as necessary for disease progression or relapse. Patients are followed every 3 months for the first year, then every 4 and 6 months for the second and third year respectively, then yearly for 5 years. PROJECTED ACCRUAL: This study will accrue 140 stage II patients for the trial portion at a rate of 40 per year over 3.5 years. At least 70 more patients will be accrued for the study portion.

Clinical Study Identifier: NCT00003122

Find a site near you

Start Over

Aberdeen Royal Infirmary

Aberdeen, United Kingdom
  Connect »

LKH Leoben

Leoben, Austria
  Connect »

Hospital Universitario de Canarias

San Cristobal de La Laguna, Spain
  Connect »

Hospital General de Galicia

Santiago de Compostela, Spain
  Connect »

Addenbrooke's Hospital

Cambridge, United Kingdom
  Connect »

Leicester Royal Infirmary

Leicester, United Kingdom
  Connect »

Christie Hospital

Manchester, United Kingdom
  Connect »

Queen's Medical Centre

Nottingham, United Kingdom
  Connect »

Southampton General Hospital

Southampton, United Kingdom
  Connect »

Royal Marsden - Surrey

Sutton, United Kingdom
  Connect »

Llandough Hospital

Llandough, United Kingdom
  Connect »

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

Receive Emails About New Clinical Trials!

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.