Last updated on July 2019

Oxygen Versus PAP for Sleep Apnea in Heart Failure

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Sleep apnea | Sleep Apnea Syndromes | Heart failure
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Veteran receiving care within the Veterans Health Administration healthcare system
  • Age 18 years
  • Physician diagnosis of chronic heart failure, American Heart Association Stage C-D
  • LVEF <45%
  • No change in active cardiac medications for 4 weeks prior to randomization
  • Ability to provide informed consent
  • Moderate to severe central or mixed central and obstructive sleep apnea, defined as an apnea-hypopnea index (AHI) 15 events per hour, with a central AHI >5 events/hour

Exclusion Criteria:

  • Hospitalization for acute decompensated HF within previous 30 days
  • Hospitalization for myocardial infarction or cardiac surgery within previous 90 days
  • Presence of a left ventricular assist device
  • History of heart transplantation
  • Poorly controlled hypertension (>170/>110)
  • Poorly controlled diabetes (HbA1c > 9.0)
  • Severe renal failure with estimated glomerular filtration rate <30 ml/min
  • Prior stroke with functional impairment or other severe, uncontrolled medical problems that may impair ability to participate in the study exams, based on medical history and review of medical records
  • Severe chronic insomnia, with reported usual sleep duration <4 hours
  • Severe daytime sleepiness, defined as Epworth Sleepiness Scale score 18 or higher or a report of falling asleep driving during the previous year, and deemed a safety risk by study physician
  • Awake resting oxyhemoglobin saturation <89%
  • Pregnancy
  • Smoking by subject or other person in the subject's bedroom, or other open flame in bedroom
  • Current use of a positive airway pressure device (including continuous or bi-level positive airway pressure or adaptive servo-ventilation) or supplemental oxygen therapy

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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