Last updated on February 2018

First Evaluation of Morphine Hydrochloride by Nebulisation in Healthy Volunteers

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Acute Pain
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Sex: We choose to include 50% of men and 50% women (this covariate will be included in the parameters to balance the randomization list).
  • Age: Healthy volunteers will be between 18 to 60 years
  • Body mass index (BMI) between 19 and 29 kg / m
  • effective contraception methods in women of childbearing age
  • Signature of informed consent
  • Affiliation to a social security scheme

Exclusion Criteria:

  • Taking painkillers long-term
  • Taking psychotropic drugs long-term
  • Healthy volunteers with chronic pain
  • Drug addiction
  • Chronic neuropsychiatric pathology which may alter the pain threshold
  • Active Smoking
  • Chronic obstructive or restrictive respiratory pathology
  • Progressive known pathology (hypertension, kidney failure, heart, liver ...)
  • Chronic treatments are prohibited except oral contraception
  • Delirium or dementia, people who did not understand the pain scales
  • Lack of understanding of the French language
  • pregnancy and lactation
  • Poor venous capital
  • History of abnormal reaction at a local / regional anesthesia
  • Heart rate : HR <50 bpm
  • Hypotension TAsyst with systolic blood pressure <100 mm Hg
  • Atrioventricular block (PR interval> 200 ms)
  • Period exclusion of another biomedical research
  • Nobody placed under judicial protection, guardianship

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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