Last updated on July 2019

Exploration by NMR Spectroscopy of the Choline Concentrations in the Insular Cortex of Patients Suffering of Neuropathic Pain Induced by Oxaliplatin


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Neuropathy | Pain
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Oxaliplatin treated patient and suffering from neuropathic pain
  • Chemotherapy (oxaliplatin based) ended
  • Pain VAS 3/10, 1 month after the chemotherapy end
  • DN4 interview score 3/7, 1 month after the chemotherapy end
  • Oxaliplatin treated patient without neuropathic pain
  • Chemotherapy (oxaliplatin based) ended
  • Pain VAS < 3/10, 1 month after the chemotherapy end
  • DN4 interview score < 3/7, 1 month after the chemotherapy end
  • All patients
  • right-handed
  • No contrindication to MRI
  • Free, written and informed consent
  • Affiliated to the french health system
  • Effective contraception for male or female of childbearing age
  • Performance score (WHO) 2

Exclusion Criteria:

  • Age < 18
  • Left-handed
  • BMI > 30 kg/m
  • Amputees of all or part of an upper limb
  • Diabetic patient
  • Painful events scheduled after enrollment (eg. surgical resection)
  • Neurological diseases (eg Parkinson's disease, stroke, migraine, fibromyalgia ...)
  • Chronic pain history before chemotherapy
  • Analgesic treatment being other than paracetamol and weak opioids
  • Alcohol consumption >3 units/day (30 g/day) for men and >2 units/day (20 g/day) for women
  • Any unbalanced progressive disease (hepatic failure, renal impairment (creatinine clearance <30 mL/min), respiratory failure, congestive heart failure, myocardial infarction within the past 6 months ...)
  • All active cancer
  • Patient with a pacemaker, a cochlear implant, metal implants, or any other magnetic element
  • Claustrophobia
  • Pregnant or lactation
  • Legal incapacity (person deprived of liberty or guardianship)
  • Psychological, social, family or geographical reasons incompatible with the study
  • Already included in another clinical trial

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.