Cerebral Amyloid Imaging Using Florbetapir (AV-45)

  • STATUS
    Recruiting
  • End date
    Sep 22, 2022
  • participants needed
    100
  • sponsor
    Centre Hospitalier Universitaire, Amiens
Updated on 22 January 2021
stroke
cognitive impairment
dementia
amyloid
amyloidosis
florbetapir
18f-av-45
cognitive assessment

Summary

This study is aimed at examining the interest of amyloid radiotracer Florbetapir (18F-AV-45) for the etiological diagnosis of poststroke cognitive impairment and dementia

Description

This study is aimed at examining the interest of amyloid radiotracer Florbetapir (18F-AV-45) for the etiological diagnosis of poststroke cognitive impairment and dementia. This study stems from two converging objectives: (1) the need to refine characteristics of vascular cognitive impairment (VCI) and dementia (VD) in order to propose diagnosis criteria of VCI and of mixed dementia and to improve diagnosis criteria of VD and (2) the need to improve the etiological diagnosis of poststroke cognitive impairment and dementia. It will take advantage from the ongoing GRECOG-VASC study (which determines the cognitive status 6 months poststroke in consecutive patients according to a standardized international battery) coordinated by the Amiens University Hospital center, the opportunity to perform amyloid imaging in vivo using Positron Emission Tomography (PET) and Florbetapir (a production site is located in the city of Amiens) and the collaboration between neurology and imaging departments of Amiens University hospital.

Details
Condition Dementia, Alzheimer's Disease, Cognitive Disorder, Cognitive Deficits, Cognitive Deficit, attention disorders, cognition disorders, cognitive disorders, disorder attention
Treatment florbetapir
Clinical Study IdentifierNCT02813434
SponsorCentre Hospitalier Universitaire, Amiens
Last Modified on22 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

patients suffering of parenchymal stroke visualized by imaging (MRI)
patients suffering from cognitive impairment on the 6 months assessment (including GRECogVASC patients)
age between 40 and 80 years
French-speaking
reliable informant
agreeing to participate in the study
affiliation to a social security system

Exclusion Criteria

women of childbearing potential (defined as pre-menopausal, less than 2 years postmenopausal, or not surgically sterile), or who are breast-feeding
history of relevant severe drug allergy or hypersensitivity
patient receiving any investigational medications at least in the 30 last days
stroke affecting the cerebellum
mental retardation
illiteracy
dementia diagnosed before stroke
history of schizophrenia or psychiatric illness requiring a stay for > 2 days in a psychiatry unit
persons placed under judicial protection
comorbidities affecting cognition (respiratory, renal, liver, heart failure)
persistent disturbance of consciousness defined by a score to item 1a of the National Institute of Health Stroke Scale (NIHSS) 1
contraindication to MRI
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