Umbilical Cord Blood Transplantation From Unrelated Donors
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- STATUS
- Recruiting
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- End date
- Jun 12, 2026
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- participants needed
- 30
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- sponsor
- University of Rochester
Summary
This study is a single-center, treatment protocol with 4 possible preparative regimens, designed to validate the process of umbilical cord blood stem cell transplantation at our institution.
Description
This study is a single-center treatment protocol with four possible preparative regimens, designed to validate the process of umbilical cord blood stem cell transplantation at our institution. Enrolled patients will receive chemotherapy +/-total body radiation as a pre-transplant conditioning regimen. Patients will then receive cord blood stem cells followed by GvHD prophylaxis that will include Tacrolimus and Mycophenolate Mofetil, or Cyclosporin A and Methylprednisolone. Multiple data points will be collected prior to, during, and following transplantation to ensure safety of the process and to evaluate the stated objectives.
Details
| Condition | Acute Leukemia, Immune Deficiency Disorder, Congenital Hematological Disorder, Metabolism Disorder, Aplastic Anemia, Myelodysplastic Syndromes, Chronic Leukemia, Lymphoma, Multiple Myeloma, Solid Tumor |
|---|---|
| Treatment | cyclophosphamide, busulfan, melphalan, Fludarabine, MESNA, Cord Blood Infusion, Total Body Irradiation 1200 cGy, Total Body Irradiation 200 cGy |
| Clinical Study Identifier | NCT03016806 |
| Sponsor | University of Rochester |
| Last Modified on | 12 July 2022 |
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