Immune System Related Kidney Disease

  • participants needed
  • sponsor
    National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Updated on 28 July 2021
autoimmune diseases
membranous nephropathy


Kidney diseases related to the immune system include, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with connective tissue disorders.

This study will allow researchers to admit and follow patients suffering from autoimmune diseases of the kidney. It will attempt to provide information about the causes and specific abnormalities associated with autoimmune kidney disease.

Patients with kidney disease as a result of their immune system, and patients with diseases of the immune system who may later develop kidney disease, will be potential subjects for this study.

Patients will undergo a history and physical examination, and standard laboratory test to more closely understand the causes, signs, symptoms, and responses to medication of these diseases. Based on these evaluations the patients may qualify as candidates for other experimental studies. At any time these patients may be asked to submit blood or urine samples for further research.


Patients with known or suspected immunologically-mediated kidney diseases, including but not limited to, nephrotic syndrome, glomerulonephritis, membranous nephropathy, lupus nephritis, and nephritis associated with other systemic or connective tissue disorders, will be evaluated at the Clinical Center. Patients who have immunologically-mediated diseases with potential for kidney disease will be evaluated as well. Studies will include characterization of the clinical and laboratory features of these disorders, studies of natural history and complications, evaluation of responses to standard treatment, and determination of the patients' eligibility to enter other experimental diagnostic or therapeutic protocols. Patients may be asked to contribute blood and/or urine samples for immunological research studies.

Condition Membranous glomerulonephritis, Nephrotic Syndrome, Nephropathy, Glomerulonephritis, Autoimmune disease, SYSTEMIC LUPUS ERYTHEMATOSUS, Lupus Nephritis, Nephritis, Kidney Disease (Pediatric), Kidney Disease, Idiopathic Membranous Nephropathy, renal disease, kidney diseases, kidney disorders, nephrologic disease, kidney disorder, disease, kidney
Clinical Study IdentifierNCT00001979
SponsorNational Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Last Modified on28 July 2021


Yes No Not Sure

Inclusion Criteria

Immunologically-mediated renal diseases, proven or suspected
Immunologically-mediated diseases with potential for kidney disease
Willingness of the patient or guardian to give informed consent

Exclusion Criteria

Concomitant medical problems which would confound the interpretation of
studies of the immunologic kidney disorder
Concomitant medical, surgical or other conditions for which inadequate
facilities or funds are available to support their care at the NIH
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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