Last updated on November 2019

Ketamine for the Rapid Treatment of Major Depressive Disorder and Alcohol Use Disorder

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Endogenous depression | Major depression | Alcohol Use Disorder
  • Age: Between 21 - 65 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Current major depressive disorder without psychotic features by DSM-5 (antidepressant regimens can be allowed and changed during the trial)
  • Montgomery-Asberg Depression Rating Scale (MADRS) 20 or higher
  • A minimum of 4 of 11 current alcohol use disorder symptoms by DSM-5
  • Heavy drinking at least 4 times in the past month ('heavy drinking' defined as 5 standard drinks per day for men and 4 standard drinks per day for women
  • Able to provide written informed consent

Exclusion Criteria:

  • Current substance use disorder by DSM-5 in the past 3 months (except alcohol, tobacco, or cannabis)
  • Current or past history of psychotic features or psychotic disorder
  • Current dementia
  • Current uncontrolled hypertension (systolic BP > 170 mm Hg or diastolic BP > 100 mm Hg)
  • Unstable medical condition or allergy to ketamine, midazolam, naltrexone, or lorazepam---clinically determined by a physician
  • Imminent suicidal or homicidal risk
  • Pregnant or nursing women, positive pregnancy test, or inadequate birth control methods in women of childbearing potential
  • Positive opioid or illicit drug screen test (except marijuana)
  • Opioid use within 10 days prior to study medication (injectable naltrexone) or risks for opioid use during the study
  • Liver enzymes that are three times higher than the upper limit of normal
  • Current use of benzodiazepine
  • Acute narrow-angle glaucoma
  • Severe sleep apnea---clinically determined by a physician

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.