Last updated on May 2018

Randomized Trial Comparing Conventional Radiotherapy With Stereotactic Radiotherapy in Patients With Bone Metastases - VERTICAL Study

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Spinal Metastases | Bone Metastases
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Radiographic evidence of bone metastases
  • For spinal lesions; per lesion no more than 3 consecutive spine segments involved with one unaffected vertebral body above and below
  • No more than 2 painful lesions needing treatment
  • Histologic proof of malignancy
  • No compression of spinal cord
  • No or mild neurological signs (i.e. radiculopathy, dermatomal sensory change, and muscle strength of involved extremity is Medical Research Council (MRC) 4/5
  • Medically inoperable or patient refused surgery
  • Karnofsky performance score (KPS) > 50
  • Numeric rating scale (NRS) > 3
  • Age > 18 years
  • Written informed consent
  • Filling out PRESENT-questionnaires

Exclusion Criteria:

  • Lesion in C1 or C2
  • Radio-sensitive histology such as multiple myeloma, lymphoma, small cell, germ cell
  • Spinal MRI cannot be completed for any reason (in according with the MRI protocol of the Department of Radiology)
  • Impossible to delineate metastasis and organs at risk (OAR) due to artifacts on CT or MRI from previous surgical stabilization
  • Unable to undergo SBRT treatment, according to treating doctor's opinion
  • Epidural disease
  • Severe, worsening or progressive neurological deficit
  • Unstable lesion requiring surgical stabilization
  • Patient with < 3 months life expectancy
  • Previous EBRT or SBRT to same level
  • Chemotherapy or systemic radionuclide delivery within 24 hours before and after SBRT

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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