Bone Mineral Density Status in Pediatric and Adolescent Survivors of Childhood Cancer With History of Bone Fracture

  • End date
    Aug 12, 2023
  • participants needed
  • sponsor
    Dana-Farber Cancer Institute
Updated on 12 August 2022
ct scan
dual-energy x-ray absorptiometry
quantitative computed tomography
childhood cancer


This research study is evaluating bone mineral density in childhood cancer survivors who have a history of bone fracture.


The purpose of this research study is to learn more about the status of bones in children and young-adults who have had bone fractures after treatment for childhood cancer. Bone complications including fracture can be important issues for some childhood cancer survivors. In this study we are measuring bone mineral density in children and young adults who have had bone fracture after treatment for childhood cancer. We will measure bone mineral density in two ways. We will use: 1) dual energy x-ray absorptiometry (also known as DXA), and 2) peripheral quantitative computed tomography (also known as pQCT).

Condition Bone Mineral Density, Childhood Cancer Survivors
Treatment Dual energy x-ray absorptiometry (DXA), Peripheral quantitative computed tomography (pQCT)
Clinical Study IdentifierNCT02355340
SponsorDana-Farber Cancer Institute
Last Modified on12 August 2022


Yes No Not Sure

Inclusion Criteria

History of childhood cancer
Age ≥ 8 years and < 20 years at time of enrollment
≥ 2 years since completion of cancer-directed therapy for first cancer
Received chemotherapy for treatment of childhood cancer
History of bone fracture after the conclusion of chemotherapy
Not currently receiving cancer-directed therapy
Signed written informed consent (by parent if patient is < 18 years of age, or by patient, if he or she is ≥18 years of age)
Patient assent for those ≥10 years of age and < 18 years of age for whom a parent provides informed consent (History of bone fracture will be based on patient/parent report of fracture occurrence and will be confirmed in review of the medical record whenever feasible.)

Exclusion Criteria

Current treatment with bisphosphonates (as of time of enrollment)
Current treatment with the anticonvulsant depakote (at time of enrollment)
Currently pregnant
Clear my responses

How to participate?

Step 1 Connect with a study center
What happens next?
  • You can expect the study team to contact you via email or phone in the next few days.
  • Sign up as volunteer to help accelerate the development of new treatments and to get notified about similar trials.

You are contacting

Investigator Avatar

Primary Contact



Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

Learn more

If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

Learn more

Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

Learn more

Similar trials to consider


Browse trials for

Not finding what you're looking for?

Every year hundreds of thousands of volunteers step forward to participate in research. Sign up as a volunteer and receive email notifications when clinical trials are posted in the medical category of interest to you.

Sign up as volunteer

user name

Added by • 



Reply by • Private

Lorem ipsum dolor sit amet consectetur, adipisicing elit. Ipsa vel nobis alias. Quae eveniet velit voluptate quo doloribus maxime et dicta in sequi, corporis quod. Ea, dolor eius? Dolore, vel!

  The passcode will expire in None.

No annotations made yet

Add a private note
  • abc Select a piece of text from the left.
  • Add notes visible only to you.
  • Send it to people through a passcode protected link.
Add a private note