Bone Mineral Density Status in Pediatric and Adolescent Survivors of Childhood Cancer With History of Bone Fracture

  • STATUS
    Recruiting
  • End date
    Aug 12, 2023
  • participants needed
    30
  • sponsor
    Dana-Farber Cancer Institute
Updated on 12 August 2022
ct scan
cancer
dual-energy x-ray absorptiometry
quantitative computed tomography
childhood cancer

Summary

This research study is evaluating bone mineral density in childhood cancer survivors who have a history of bone fracture.

Description

The purpose of this research study is to learn more about the status of bones in children and young-adults who have had bone fractures after treatment for childhood cancer. Bone complications including fracture can be important issues for some childhood cancer survivors. In this study we are measuring bone mineral density in children and young adults who have had bone fracture after treatment for childhood cancer. We will measure bone mineral density in two ways. We will use: 1) dual energy x-ray absorptiometry (also known as DXA), and 2) peripheral quantitative computed tomography (also known as pQCT).

Details
Condition Bone Mineral Density, Childhood Cancer Survivors
Treatment Dual energy x-ray absorptiometry (DXA), Peripheral quantitative computed tomography (pQCT)
Clinical Study IdentifierNCT02355340
SponsorDana-Farber Cancer Institute
Last Modified on12 August 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

History of childhood cancer
Age ≥ 8 years and < 20 years at time of enrollment
≥ 2 years since completion of cancer-directed therapy for first cancer
Received chemotherapy for treatment of childhood cancer
History of bone fracture after the conclusion of chemotherapy
Not currently receiving cancer-directed therapy
Signed written informed consent (by parent if patient is < 18 years of age, or by patient, if he or she is ≥18 years of age)
Patient assent for those ≥10 years of age and < 18 years of age for whom a parent provides informed consent (History of bone fracture will be based on patient/parent report of fracture occurrence and will be confirmed in review of the medical record whenever feasible.)

Exclusion Criteria

Current treatment with bisphosphonates (as of time of enrollment)
Current treatment with the anticonvulsant depakote (at time of enrollment)
Currently pregnant
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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