Last updated on February 2018

Study to Improve OS in 18 to 60 Year-old Patients Comparing Daunorubicin Versus High Dose Idarubicin Induction Regimens High Dose Versus Intermediate Dose Cytarabine Consolidation Regimens and Standard Versus MMF Prophylaxis of GvHD in Allografted Patients in First CR


Brief description of study

This open label, multicenter phase II/III study with multiple randomization phases at differents stages of AML treatment (induction, consolidation and HSCT where applicable) is designed to improve OS in younger (18 to 60 year-old) patients, with AML risk-adapted patient strategies. Within the intermediate risk AML group, optimal GvHD prophylaxis following allogeneic SCT in first CR, after either myeloablative (MAC) or reduced intensity (RIC) conditioning, will also be evaluated. With an adaptative design, this clinical trial could test up to 3 novel AML agents of interest.

Clinical Study Identifier: NCT02416388

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Jean-Pierre Marolleau

CH Amiens H pital Sud
Amiens, France
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Mathilde Hunault

CHU Angers
Angers, France
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Ahmad Al Jijakli

CH Victor Dupouy
Argenteuil, France
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Anne Banos

Centre Hospitalier de la C te Basque
Bayonne, France
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Fabrice Larosa

H pital Jean Minjoz
Besancon, France
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Alain Saad

CH Beziers
Beziers, France
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Claude Gardin

H pital Avicenne
Bobigny, France
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Arnaud Pigneux

CH Bordeaux
Bordeaux, France
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Bachra Choufi

H pital du Dr Duchenne
Boulogne sur Mer, France
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Gaelle Guillerm

H pital Morvan
Brest, France
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Sylvain Chantepie

CH Caen
Caen, France
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Carole Exbrayat

Clinique du parc
Castelnau Le lez, France
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Ioana Vaida

Centre Hospitalier Ren Dubos
Cergy Pontoise, France
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Jean-Valère Malfuson

HIA Percy
Clamart, France
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Aurelie Ravinet

CHU Estaing
Clermont-Ferrand, France
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Celia Salanoubat

Centre Hospitalier Sud Francilien
Corbeil Essonnes, France
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Mathilde Hunault, PD

H pital Henri Mondor
Créteil, France
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Denis Caillot

CHU de Dijon
Dijon, France
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Maxime Bemba

CH Dunkerque
Dunkerque, France
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Jean-Yves Cahn

H pital Michallon
Grenoble, France
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Philippe Rousselot

CH Versailles
Le Chesnay, France
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Laure STALNIKIEWICZ

CH Lens
Lens, France
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Bruno Quesnel

CHRU de Lille, H pital Huriez
Lille, France
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Nathalie Cambier

H pital St Vincent de Paul
Lille, France
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Pascal Turlure

CHU de Limoges
Limoges, France
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Amine Belhabri

Centre Leon Berard (CLB)
Lyon, France
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Xavier Thomas

CH Lyon Sud
Lyon, France
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Norbert Vey

Institut Paoli Calmettes
Marseille, France
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Jamilé Frayfer

CH Meaux
Meaux, France
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Veronique Dorvaux

CHR Metz Thionville_H pital de Mercy
Metz, France
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Yosr Hicheri

H pital Saint Eloi
Montpellier, France
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Mario Ojeda-Uribe

CH Mulhouse
Mulhouse, France
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Pierre Peterlin

CH H tel Dieu
Nantes, France
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Lauris Gastaud

Centre Antoine Lacassagne
Nice, France
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Thomas Cluzeau

CHU Nice
Nice, France
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Eric Jourdan

CHRU de N mes
Nîmes, France
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Didier Bouscary

H pital Cochin
Paris, France
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Madalina Uzunov

H pital La Piti Salp tri re
Paris, France
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Felipe Suarez

H pital Necker Enfants Malades
Paris, France
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Ollivier Legrand

H pital Saint Antoine
Paris, France
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Emmanuel Raffoux

H pital St Louis
Paris, France
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Laurence Sahnes

Centre Hospitalier Saint Jean
Perpignan, France
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Maria Pilar Gallego-Hernanz

CHU de Poitiers
Poitiers, France
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Chantal Himberlin

H pital Robert Debr
Reims, France
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Marc Bernard

CH Pontchaillou
Rennes, France
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Isabelle Plantier

Hopital Victor Provo
Roubaix, France
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Emilie Lemasle

Centre Henri Becquerel
Rouen, France
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Jacques Vargaftig

H pital Ren Huguenin
St Cloud, France
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Emmanuelle Tavernier

Institut de Canc rologie Lucien Neuwirth
St Priest en Jarez, France
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Bruno Lioure

H pital Hautepierre
Strasbourg, France
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Christian Recher

IUCT Toulouse
Toulouse, France
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Emmanuel Gyan

CHU Bretonneau
Tours, France
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Jose Fernandes

CH Valenciennes
Valenciennes, France
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Gabrielle Roth-Guepin

H pitaux de Brabois_CHU Nancy
Vandoeuvre-les-Nancy, France
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Stephane De Botton

Institut de Canc rologie Gustave Roussy
Villejuif, France
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Recruitment Status: Open


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