The Role of Endothelium A and EGFR Receptor in Fibrocytes From Asthma With Obstructive Sleep Apnea

  • End date
    Apr 23, 2022
  • participants needed
  • sponsor
    Chang Gung Memorial Hospital
Updated on 23 January 2021
forced expiratory volume


The investigators will compare the circulating fibrocyte proportion in asthmatic patients with obstructive sleep apnea (OSA) and not with OSA In addition, the investigators will compare the expression of epidermal growth factor receptor (EGFR), endothelin A receptor (ETAR) and connective tissue growth factor (CTGF) The association of those factors and annual decline of forced expiratory volume in 1 second (FEV1) will be performed


Asthma is characterized by airflow obstruction, chronic airway inflammation and remodeling. The investigators' report has shown directly the relationship between fibrocytes, and chronic airflow obstruction with rapid decline in FEV1 in asthma. Asthma concomitant of obstructive sleep apnea (OSA) may appear intermittent hypoxia and result in the frequent attack of asthma symptoms. In animal model, hypoxia may increase the circulating fibrocytes, thus play a role in pulmonary hypertension. The investigators' published paper also showed that an increased expression of EGFR, ETAR and Vascular endothelial growth factor receptor (VEGFR) in circulating fibrocytes in chronic obstructive asthmatics. It is unknown whether circulating fibrocytes from asthma with OSA have the higher expression of EGFR, connective tissue growth factor receptor, VEGFR and ETAR compared to asthma without OSA. The investigators are also interested in whether proliferation and differentiation of fibrocytes are different between asthmatics with or without concomitant of OSA. The investigators will study the correlation between the percentage of circulating fibrocytes and the oxygen desaturation index (ODI) and severity of sleep apnea to clarify the role of hypoxia, which contributing to chronic asthma.

Condition Asthma, Obstructive sleep apnea, Allergies & Asthma, Asthma (Pediatric), obstructive sleep apnoea, obstructive sleep apnea syndrome, asthmatic, bronchial asthma
Treatment Continuous positive airway pressure (CPAP)
Clinical Study IdentifierNCT02749565
SponsorChang Gung Memorial Hospital
Last Modified on23 January 2021


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Inclusion Criteria

Is your age greater than or equal to 18 yrs?
Gender: Male or Female
Do you have any of these conditions: Asthma or Obstructive sleep apnea?
Do you have any of these conditions: Asthma (Pediatric) or obstructive sleep apnea syndrome or asthmatic or Allergies & Asthma or Asthma or obstructive sleep apnoea or bronchial asthma or...?
clinical diagnosis of asthma

Exclusion Criteria

chronic obstructive pulmonary disease (COPD)
cystic fibrosis
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