Response-based Treatment of High-risk Neuroblastoma

  • End date
    Mar 21, 2023
  • participants needed
  • sponsor
    Samsung Medical Center
Updated on 21 January 2021


The purpose of this study is to improve outcome of high risk neuroblastoma by tailoring the treatment intensity of tandem high dose chemotherapy according to the treatment response to induction chemotherapy.


Although the outcome of high-risk neuroblastoma improved after the introduction of high-dose chemotherapy and autologous stem cell transplantation (HDCT/autoSCT), the outcome still needs to be unsatisfactory.

In the investigator's previous study, good responders who had greater reduction of tumor volume after induction chemotherapy showed lower relapse-free survival compared to poor responders.Simultaneously, the reduction in tumor volume also was greater in patients who died of treatment related mortality than patients who had relapsed tumors. These findings suggest that tailoring treatment intensity according to the early tumor response to induction chemotherapy may improve patient outcomes. So, in this study investigators tailored the treatment intensity of high dose chemotherapy according to the treatment response to induction chemotherapy.

Condition Newly Diagnosed High Risk Neuroblastoma
Treatment cyclophosphamide, cisplatin, etoposide, ifosfamide, carboplatin, isotretinoin, Radiotherapy, doxorubicin, Interleukin-2, Tandem HDCT/auto-SCT, MIBG, MIBG
Clinical Study IdentifierNCT02771743
SponsorSamsung Medical Center
Last Modified on21 January 2021


Yes No Not Sure

Inclusion Criteria

Patients with newly diagnosed high risk neuroblastoma
Patients with informed consent

Exclusion Criteria

Patients with progressive disease or relapse
Patients who underwent high dose chemotherapy before
Patients with organ dysfunction as follows (creatinine elevation > 3 x upper limit of normal, Total bilirubin > 3 x upper limit of normal, aspartate transaminase/alanine transaminase > 5 x upper limit of normal), ejection fraction <40%
Pregnant or nursing women
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Additional screening procedures may be conducted by the study team before you can be confirmed eligible to participate.

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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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