The Role of Androgen Deprivation Therapy In Cardiovascular Disease - A Longitudinal Prostate Cancer Study (RADICAL PC1) & A RAndomizeD Intervention for Cardiovascular and Lifestyle Risk Factors in Prostate Cancer Patients (RADICAL PC2) (RADICALPC)
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- STATUS
- Recruiting
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- End date
- Dec 28, 2025
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- participants needed
- 6000
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- sponsor
- McMaster University
Summary
RADICAL PC1 is a prospective cohort study of men with a new diagnosis of prostate cancer. RADICAL PC2 is a randomized, controlled trial of a systematic approach to modifying cardiovascular and lifestyle risk factors in men with a new diagnosis of prostate cancer.
Description
RADICAL PC describes two prospective studies, one of which is embedded in the other. RADICAL PC1 is a prospective cohort study of men within one year of their first diagnosis of prostate cancer, or treated with Androgen Deprivation Therapy for the first time within 6 months prior to enrollment visit, or to be treated with Androgen Deprivation Therapy for the first time within one month after the enrollment visit. Its goal will be to identify factors associated with the development of cardiovascular disease among men with prostate cancer, with a particular focus on Androgen Deprivation Therapy. RADICAL PC2 is a randomized, controlled trial embedded in RADICAL PC1. RADICAL PC2 will test a systematic approach to modifying cardiovascular and lifestyle risk factors in men within one year of their first diagnosis of prostate cancer, or treated with Androgen Deprivation Therapy for the first time within 6 months prior to enrollment visit, or to be treated with Androgen Deprivation Therapy for the first time within one month after the enrollment visit.
Details
| Condition | Prostate Cancer, Cardiovascular Disease |
|---|---|
| Treatment | Exercise, Smoking cessation, ACE inhibitor, nutrition, Antiplatelet agent, such as Aspirin, or other low-dose antiplatelet agent, Statin, such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin), Statin (such as Simvastatin, Atorvastatin, Rosuvastatin, Pravastatin) |
| Clinical Study Identifier | NCT03127631 |
| Sponsor | McMaster University |
| Last Modified on | 28 October 2022 |
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