Cytokines Associated With Cord Blood Cell Therapy for Neonatal Encephalopathy

    Not Recruiting
  • participants needed
  • sponsor
    Neonatal Encephalopathy Consortium, Japan
Updated on 23 January 2021
Nagoya University Hospital (1.8 mi away) Contact
+4 other location


This is a observational study to assess the effects of and to explore the mechanisms of autologous umbilical cord blood cell therapy for neonatal encephalopathy by way of measuring serum cytokines.


The effects and mechanisms of umbilical cord blood cell therapy for perinatal brain injury are not well understood. This is a multicenter study to measure serum levels of inflammatory cytokines and trophic factors associated with perinatal brain injury and repair in term gestation newborns with neonatal encephalopathy (hypoxic-ischemic encephalopathy). This study proceeds along with the study "Autologous cord blood cell therapy for neonatal encephalopathy ( identifier: NCT02256618)". Blood samples are obtained before the first cell infusion, and subsequently 2h, 24h, 48h, and 7 days after the first cell infusion. Blood samples are obtained in the same manner from newborns with neonatal encephalopathy who are not receiving the cell therapy.

Condition Neonatal Encephalopathy
Treatment Autologous cord blood cell therapy
Clinical Study IdentifierNCT02455830
SponsorNeonatal Encephalopathy Consortium, Japan
Last Modified on23 January 2021

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