Prediction of Risk of Hypotension in Hemodialysis

  • participants needed
  • sponsor
    University Hospital, Clermont-Ferrand
Updated on 15 June 2021
heart disease
renal failure


The main objective is to establish a statistical predictive model of the risk of intradialytic hypotension during hemodialysis (HD) or hemodiafiltration (HDF) sessions based on the measurement of residual blood volume and excess extracellular hydration. The secondary objective is to study the impact of dysfunction in the mechanisms of compensation for decreased blood volume (heart disease, neuropathy, drugs) on the risk of intradialytic hypotension.


The duration of the study is 4 weeks for each patient. It will first be carried out a spectral analysis of heart rate variability (CHU of Clermont Ferrand only) and a measurement of intracellular and extracellular volumes by bioimpedancemetry. During the next 9 sessions, the decrease in the VSR will be recorded using an optical haematocrit measurement system. Blood pressure and heart rate will be measured every 30 minutes using an automatic blood pressure monitor and whenever the patient's nurse deems it necessary.

Condition Hypotension, Vascular Diseases, Hemodialysis, Low Blood Pressure (Hypotension), Chronical Kidney Disease, Residual Blood Volume
Treatment hemodialysis
Clinical Study IdentifierNCT03350308
SponsorUniversity Hospital, Clermont-Ferrand
Last Modified on15 June 2021

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