Last updated on April 2019

Targeted Therapy Directed by Genetic Testing in Treating Patients With Advanced Refractory Solid Tumors Lymphomas or Multiple Myeloma (The MATCH Screening Trial)


Brief description of study

This phase II MATCH trial studies how well treatment that is directed by genetic testing works in patients with solid tumors or lymphomas that have progressed following at least one line of standard treatment or for which no agreed upon treatment approach exists. Genetic tests look at the unique genetic material (genes) of patients' tumor cells. Patients with genetic abnormalities (such as mutations, amplifications, or translocations) may benefit more from treatment which targets their tumor's particular genetic abnormality. Identifying these genetic abnormalities first may help doctors plan better treatment for patients with solid tumors, lymphomas, or multiple myeloma.

Detailed Study Description

PRIMARY OBJECTIVES:

I. To evaluate the proportion of patients with objective response (OR) to targeted study agent(s) in patients with advanced refractory cancers/lymphomas/multiple myeloma.

SECONDARY OBJECTIVES:

I. To evaluate the proportion of patients alive and progression free at 6 months of treatment with targeted study agent in patients with advanced refractory cancers/lymphomas/multiple myeloma.

II. To evaluate time until death or disease progression. III. To identify potential predictive biomarkers beyond the genomic alteration by which treatment is assigned or resistance mechanisms using additional genomic, ribonucleic acid (RNA), protein and imaging-based assessment platforms.

IV. To assess whether radiomic phenotypes obtained from pre-treatment imaging and changes from pre- through post-therapy imaging can predict objective response and progression free survival and to evaluate the association between pre-treatment radiomic phenotypes and targeted gene mutation patterns of tumor biopsy specimens.

OUTLINE

STEP 0 (Screening): Patients undergo biopsy along with molecular characterization of the biopsy material for specific, pre-defined mutations, amplifications, or translocations of interest via tumor sequencing and immunohistochemistry. Consenting patients also undergo collection of blood samples for research purposes.

STEPS 1, 3, 5, 7 (Treatment): Patients are assigned to 1 of 35 treatment subprotocols based on molecularly-defined subgroup. (See Arms Section)

STEPS 2, 4, 6 (Screening): Patients experiencing disease progression on the prior Step treatment or who could not tolerate the assigned treatment undergo review of their previous biopsy results to determine if another treatment is available or undergo another biopsy. Patients may have a maximum of 2 screening biopsies and 2 treatments per biopsy.

STEP 8 (Optional Research): Consenting patients undergo end-of-treatment biopsy and collection of blood samples for research purposes.

After completion of study treatment, patients are followed up every 3 months for 2 years and then every 6 months for 1 year.

Clinical Study Identifier: NCT02465060

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Aria Health-Torresdale Campus

Philadelphia, PA United States
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Nazareth Hospital

Philadelphia, PA United States
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Phoenixville Hospital

Phoenixville, PA United States
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Allegheny General Hospital

Pittsburgh, PA United States
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West Penn Hospital

Pittsburgh, PA United States
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Community Medical Center

Scranton, PA United States
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Geisinger Medical Group

State College, PA United States
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Mount Nittany Medical Center

State College, PA United States
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Chester County Hospital

West Chester, PA United States
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Reading Hospital

West Reading, PA United States
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UPMC Susquehanna

Williamsport, PA United States
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Lankenau Medical Center

Wynnewood, PA United States
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Newport Hospital

Newport, RI United States
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Rhode Island Hospital

Providence, RI United States
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Women and Infants Hospital

Providence, RI United States
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Miriam Hospital

Providence, RI United States
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AnMed Health Cancer Center

Anderson, SC United States
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Beaufort Memorial Hospital

Beaufort, SC United States
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Roper Hospital

Charleston, SC United States
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Gibbs Cancer Center-Gaffney

Gaffney, SC United States
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Saint Francis Hospital

Greenville, SC United States
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Greenville Memorial Hospital

Greenville, SC United States
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Saint Francis Cancer Center

Greenville, SC United States
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Self Regional Healthcare

Greenwood, SC United States
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South Carolina Cancer Specialists PC

Hilton Head Island, SC United States
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Spartanburg Medical Center

Spartanburg, SC United States
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Rapid City Regional Hospital

Rapid City, SD United States
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Avera Cancer Institute

Sioux Falls, SD United States
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Memorial Hospital

Chattanooga, TN United States
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Meharry Medical College

Nashville, TN United States
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Memorial GYN Plus

Ooltewah, TN United States
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M D Anderson Cancer Center

Houston, TX United States
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University Hospital

San Antonio, TX United States
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Sandra L Maxwell Cancer Center

Cedar City, UT United States
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Farmington Health Center

Farmington, UT United States
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Logan Regional Hospital

Logan, UT United States
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Riverton Hospital

Riverton, UT United States
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LDS Hospital

Salt Lake City, UT United States
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South Jordan Health Center

South Jordan, UT United States
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Norris Cotton Cancer Center-North

Saint Johnsbury, VT United States
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Danville Hematology Oncology

Danville, VA United States
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Inova Fairfax Hospital

Falls Church, VA United States
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Augusta Health Cancer Center

Fishersville, VA United States
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Sovah Health Martinsville

Martinsville, VA United States
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Virginia Cancer Institute

Richmond, VA United States
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Harrison Medical Center

Bremerton, WA United States
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Saint Elizabeth Hospital

Enumclaw, WA United States
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Saint Francis Hospital

Federal Way, WA United States
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Northwest Cancer Clinic

Kennewick, WA United States
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Saint Clare Hospital

Lakewood, WA United States
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Skagit Valley Hospital

Mount Vernon, WA United States
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Jefferson Healthcare

Port Townsend, WA United States
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Peninsula Cancer Center

Poulsbo, WA United States
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Valley Medical Center

Renton, WA United States
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Legacy Salmon Creek Hospital

Vancouver, WA United States
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United Hospital Center

Bridgeport, WV United States
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Monongalia Hospital

Morgantown, WV United States
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Duluth Clinic Ashland

Ashland, WI United States
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Marshfield Clinic-Chippewa Center

Chippewa Falls, WI United States
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Aurora Health Center-Fond du Lac

Fond Du Lac, WI United States
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Aurora Health Care Germantown Health Center

Germantown, WI United States