Neoadjuvant Vemurafenib + Cobimetinib + Atezolizumab in Melanoma: NEO-VC

  • End date
    Dec 23, 2021
  • participants needed
  • sponsor
    University Hospital Tuebingen
Updated on 10 February 2021
Thomas Eigenlter, Dr.
Primary Contact
Department of Dermatology & Skin Cancer University Hospital La Timone, Aix-Marseille University (0.0 mi away) Contact
+9 other location
platelet count
measurable disease
cancer treatment
immunologic adjuvant


Evaluation of the efficacy, safety and biologic effects of neo-adjuvant treatment with vemurafenib + cobimetinib + atezolizumab in patients with limited metastasis of melanoma in stage IIIC/IV melanoma.


Patients with hardly resectable/unresectable limited metastasis in malignant melanoma stages IIIC/IV (AJCC 2010) carrying the BRAF V600 mutation, in order to achieve operability are enrolled in the NEO-VC-study. The main aim of this study is to achieve operability in a higher percentage of patients by neoadjuvant treatment through shrinkage of the tumors. Patients with operable stage IV disease show an impressive survival benefit with long term (5 y.) survival rates around 30 %. Only a percentage of up to 20 % can presently be treated by complete metastasectomy. This percentage may be enlarged by pre-treatment with an efficacious antitumor drug.

Condition melanoma, Metastatic Melanoma, Malignant Melanoma
Treatment Vemurafenib, Cobimetinib, Atezolizumab, Vemurafenib + cobimetinib
Clinical Study IdentifierNCT02303951
SponsorUniversity Hospital Tuebingen
Last Modified on10 February 2021

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