TACE+RFA Versus TACE Alone for Intermediate-stage Hepatocellular Carcinoma

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  • sponsor
    Ming Zhao
Updated on 21 January 2021
tumour thrombus
transcatheter arterial chemoembolisation
vascular invasion


The current standard treatment for intermediate-stage HCC (BCLC stage B) is transcatheter arterial chemoembolization (TACE) alone.The combination of TACE with RFA has also reported to be an effective treatment for HCC. Some prospective studies have shown TACE combined RFA to have better efficacy than any of them alone for early stage HCC (single tuomor 5 cm). However, to the investigators' knowledge, there have not been any prospective studies to assess whether TACE combined sequentially with RFA is more effective than TACE alone for the treatment of intermediate-stage HCC. The investigators hypothesized that the combination of TACE and RFA might result in better patient survival than TACE alone. Thus, the purpose of this study was to prospectively compare the effects of sequential TACE-RFA with TACE alone for the treatment of intermediate-stage HCC. Intermediate-stage HCC in this study was defined as 2-3 intrahepatic lessions, largest tumor size 3-7 cm or 4-10 intrahepatic lessions, largest tumor size 7 cm; ECOG-PS 0;Child-pugh A or B;no tumor thrombus or extrahepatic metastases.

Condition Adenocarcinoma, Malignant Adenoma, Adenocarcinoma, HEPATIC NEOPLASM, Liver Cancer, HEPATOCELLULAR CARCINOMA, Chemoembolization, Therapeutic, Ablation Techniques, RFA, Liver Cancer, Malignant Adenoma, liver cell carcinoma, Ablation Techniques, RFA
Treatment TACE, RFA
Clinical Study IdentifierNCT02435953
SponsorMing Zhao
Last Modified on21 January 2021


Yes No Not Sure

Inclusion Criteria

Multiple HCC (2-3 lesions), largest lesion 3-7 cm in diameter, or multiple HCC (4-10 lesions), each 7 cm in diameter
No vascular invasion or etrahepatic metastases
Eastern Cooperative Oncology Group Performance Status 0-1
Child-Pugh Stage A or B
Treatment naive

Exclusion Criteria

A platelet counts of <40109/Lprothrombin time activity <40%
Albumin >2.8 g/dL, total bilirubin <51.3 umol/L; alanine aminotransferase (ALT) and aspartate transaminaseAST<5 times of upper limit
No evaluale target lesions
Uncontrolled or refractory ascites, ongoing variceal bleeding or encephalopathy
Severe heart, brain or kidney diseases
Previous or concurrent cancer that is distinct in primary site or histology from HCC
Pregnant women or lactating women
Be allergic to adriamycin, lobaplatin, mitomycin and iodized oil
Clear my responses

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