Daily Bitemporal Low-frequency Transcranial Random Noise Stimulation in Tinnitus (tRNS2-tin)

  • End date
    Dec 3, 2022
  • participants needed
  • sponsor
    University of Regensburg
Updated on 3 February 2021


Stimulation of the left and right auditory cortex with daily low-frequency transcranial random noise stimulation (tRNS) is used to modulate the neural pathways involved in chronic tinnitus.


Tinnitus is the phantom auditory perception of sound in the absence of an external or internal acoustic stimulus. It is a frequent problem which can interfere significantly with the ability to lead a normal life. Tinnitus has been shown to be generated in the brain, as a result of functional reorganization of auditory neural pathways and the central auditory system. These changes are represented by hyper-activity and hyper-synchronicity in the auditory pathway. Treatment remains difficult. Non-invasive brain stimulation methods has shown to be effective in the treatment of chronic tinnitus with moderate effect size. First data suggest the use of transcranial random noise stimulation (tRNS) over both auditory cortices as new and highly effective treatment. Low-frequency (lf; <100Hz) tRNS might be highly effective in tackling hyper-synchronised cell assemblies. Daily lf-tRNS (2 weeks) will be examined with regard to feasibility, safety and clinical efficacy in patients suffering from chronic tinnitus in an one-arm pilot trial.

Condition Chronic Tinnitus
Treatment lf-tRNS
Clinical Study IdentifierNCT02615600
SponsorUniversity of Regensburg
Last Modified on3 February 2021


Yes No Not Sure

Inclusion Criteria

diagnosis of bothersome, subjective chronic tinnitus
diagnosis: duration of tinnitus more than 6 months

Exclusion Criteria

objective tinnitus
irregular head shap below the electrodes
eczema on the head
treatable cause of the tinnitus
involvement in other treatments for tinnitus at the same time
clinically relevant psychiatric comorbidity
clinically relevant unstable internal or neurological comorbidity
history of or evidence of significant brain malformation or neoplasm, head injury
cerebral vascular events
neurodegenerative disorder affecting the brain or prior brain surgery
metal objects in and around body that can not be removed
alcohol or drug abuse
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