Last updated on January 2019

Metagenomic Evaluation of the Gut Microbiome in Patients With Lynch Syndrome and Other Hereditary Colonic Polyposis Syndromes


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Hereditary Colonic Polyposis Syndromes | Lynch Syndrome
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Male or Female age 18 or older
  • Hereditary colorectal cancer syndrome with one of the following:
  • Lynch syndrome, as defined by the presence of a deleterious germline mutation in the MLH1, MSH2, MSH6, PMS2 or EPCAM genes
  • Other hereditary colonic polyposis syndromes, as defined by the presence of a deleterious germline mutation in any one of the following polyposis genes (APC, biallelic MYH, STK11, SMAD4, BMPR1A, or other CRC-risk associated genes at discretion of PI)

Exclusion Criteria:

  • Unable to provide informed consent for testing
  • Unable to complete English language questionnaire
  • Receiving active chemotherapy
  • Having completed active chemotherapy less then 12 months prior to day of scheduled lower endoscopy
  • No infectious or drug induced colitis less then 12 months prior to day of scheduled lower endoscopy
  • No history of inflammatory colitis (Crohn's disease or ulcerative colitis)

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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