Last updated on April 2018

Prospective Multi-Center Evaluation of the Efficacy of Peripheral Trigger Decompression Surgery for Migraine Headaches

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Migraine
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Patients with migraines related to a trigger site at the location of a branch of a cranial nerve (frontal, temporal, occipital)
  • Patients with chronic migraine (15 days per month) as dictated by the FDA indication for botulinum, and as diagnosed by a board-certified neurologist
  • Patients with episodic migraines
  • Those patients are included because there is no consensus whether surgical decompression is effective for chronic migraines only, or for chronic and episodic migraines. One of the goals of this trial is to determine this.
  • Patients who respond to diagnostic botulinum toxin injection or to a diagnostic anesthetic block
  • Patients who have failed 2 of 3 classes of preventative migraine medications

Exclusion Criteria:

  • Patients deemed by the authors or the neurologist to not have migraine headaches, but an alternative diagnosis
  • Patients with systemic conditions that make them poor candidates for surgery (coronary artery disease, uncontrolled diabetes mellitus, etc)
  • Patients with migraines related to inferior turbinate hypertrophy or septal deviation
  • Patients with a frontal, temporal or occipital trigger point who do not respond to a diagnostic botulinum toxin injection or to a diagnostic anesthetic block
  • Hypersensitivity to any botulinum toxin preparation or to any of the components in the formulation
  • Infection at the proposed injection site for botulinum
  • Patients with trigger points at minor trigger sites (lesser occipital nerve, third occipital nerve)

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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