Impact of Thermocoagulation During Invasive EEG Monitoring in Children With Focal Drug-resistant Epilepsies (COAG)

  • End date
    Jun 11, 2024
  • participants needed
  • sponsor
    Fondation Ophtalmologique Adolphe de Rothschild
Updated on 4 October 2022
eeg monitoring
partial epilepsy


When focal epilepsies become drug-resistant, it could be eligible for cortical surgical resection. Therefore, an invasive EEG monitoring with depth electrodes is often needed during presurgical evaluation. Some of these children can have access to thermocoagulation inside the ictal onset zone, at the end of the monitoring and before to remove the electrodes. These thermocoagulations can disorganize the epileptogenic network thanks to millimetric cortical lesions around the electrodes. The aim is to stop or at least, to reduce the seizure frequency for few weeks or months. This could be a benefit for the child, and also a confirmation of the ictal onset zone and guide the surgeon. This technique is currently used in adult population for years, but remains very rare in children.

Condition Epilepsy
Treatment Thermocoagulation, Thermocoagulation
Clinical Study IdentifierNCT02886650
SponsorFondation Ophtalmologique Adolphe de Rothschild
Last Modified on4 October 2022


Yes No Not Sure

Inclusion Criteria

age 18 month to 17 years old
focal drug-resistant epilepsy
small size lesion (1 or 2 gyri) or cryptogenic epilepsy
indication for EEG monitoring with depth electrodes during presurgical evaluation

Exclusion Criteria

formal contraindication to surgery or anaesthesia
functional area or potentially large epileptic area
refusal to participate in the study
no health insurance coverage
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