Ticagrelor Monotherapy After 3 Months in the Patients Treated With New Generation Sirolimus Stent for Acute Coronary Syndrome (TICO Study)

  • End date
    May 22, 2023
  • participants needed
  • sponsor
    Yonsei University
Updated on 22 January 2021
antiplatelet therapy


To compare the clinical outcomes of dual antiplatelet therapy with aspirin and ticagrelor vs. ticagrelor monotherapy at 3 months after PCI in patients with acute coronary syndrome.

Condition Acute Coronary Syndrome, Ischemic Heart Disease, Cardiac Ischemia, Myocardial Ischemia, Cardiac Ischemia, Myocardial Ischemia, acute coronary syndromes
Treatment Ticagrelor monotherapy, Ticagrelor with Aspirin DAPT(dual antiplatelet treatment)
Clinical Study IdentifierNCT02494895
SponsorYonsei University
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

Patients 19 years old
Patients who received new generation sirolimus-eluting (Osiro) stent implantation for treating ACS
Patients without significant clinical events such as MI, stent thrombosis or revascularization until 3 months after PCI
Provision of informed consent

Exclusion Criteria

Age > 80 years
Increased risk of bleeding, anemia, thrombocytopenia
A need for oral anticoagulation therapy
Pregnant women or women with potential childbearing
Life expectancy < 1 year
Patients who treated with strong CYP3A4 inhibitors (e.g. ketoconazole, clarithromycin, nefazodone, ritonavir, or atazanavir)
Patients who had history of intracranial hemorrhage
Moderate to severe hepatic dysfunction
Increased risk of bradycardia-related symptom (Guidance and reference)
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