Platinum Based Chemotherapy or Capecitabine in Treating Patients With Residual Triple-Negative Basal-Like Breast Cancer Following Neoadjuvant Chemotherapy

  • STATUS
    Recruiting
  • End date
    May 31, 2024
  • participants needed
    562
  • sponsor
    ECOG-ACRIN Cancer Research Group
Updated on 27 May 2020
Investigator
Joseph M. Wiley
Primary Contact
Sinai Hospital of Baltimore (7.7 mi away) Contact
+702 other location
cancer
tubal ligation
hysterectomy
metastatic disease
carcinoma
breast cancer
warfarin
oophorectomy
treatment regimen
international normalized ratio
residual tumor
anthracyclines
experimental drug
weak
metastasis
neutrophil count
carboplatin
capecitabine
immunohistochemistry
tumor cells
epidermal growth factor receptor
primary tumor
carcinoma in situ
lobular carcinoma
biomarker analysis
denosumab
adjuvant therapy
human epidermal growth factor
neuropathy
erbb2
gnrh
invasive breast cancer
taxane
breast conserving surgery
triple-negative breast cancer
mastectomy
lumpectomy
adjuvant chemotherapy
ductal carcinoma in situ
axillary lymph node dissection
lobular carcinoma in situ
sentinel node
breast-conserving surgery
ductal carcinoma
sentinel lymph node biopsy
invasive cancer

Summary

This randomized phase III trial studies how well cisplatin or carboplatin (platinum based chemotherapy) works compared to capecitabine in treating patients with remaining (residual) basal-like triple-negative breast cancer following chemotherapy after surgery (neoadjuvant). Drugs used in chemotherapy, such as cisplatin, carboplatin and capecitabine, work in different ways to stop the growth of tumor cells, either by killing the cells, by stopping them from dividing, or by stopping them from spreading. It is not yet known whether cisplatin or carboplatin is more effective than capecitabine in treating patients with residual triple negative basal-like breast cancer.

Description

PRIMARY OBJECTIVES:

I. To compare the invasive disease-free survival (IDFS) in triple-negative breast cancer (TNBC) patients with residual basal-like disease after neoadjuvant chemotherapy who are randomized to post-preoperative platinum based chemotherapy with those who are randomized to capecitabine.

SECONDARY OBJECTIVES:

I. To evaluate overall survival (OS) and response-free survival (RFS) in the two arms in patients with TNBC with residual basal-like disease after neoadjuvant chemotherapy.

II. To characterize the side effects and tolerability of each platinum agent (cisplatin and carboplatin) as well as capecitabine in patients with TNBC with residual disease after neoadjuvant chemotherapy.

III. To identify the rate of basal-like gene expression using prediction analysis of microarray 50 (PAM50) analysis by digital messenger ribonucleic acid (mRNA) quantitation amongst drug-resistant residual TNBC after neoadjuvant chemotherapy.

IV. To compare the IDFS in TNBC patients with residual non-basal-like disease after neoadjuvant chemotherapy who are randomized to post-preoperative platinum based chemotherapy with those who are randomized to capecitabine (exploratory analysis).

V. To assess the difference in health-related quality of life (HRQL) between the platinum based and capecitabine chemotherapy arms.

VI. To describe the rate of neurotoxicity over time in the platinum arm, the rate of medication adherence in the capecitabine arm and the rates of amenorrhea in both arms (exploratory).

OUTLINE: Patients are randomized to 1 of 3 treatment arms.

ARM A (closed to accrual 05/16/2016): Patients undergo observation.

ARM B: Patients receive cisplatin intravenously (IV) or carboplatin IV on day 1. Treatment repeats every 3 weeks for 4 courses in the absence of disease progression or unacceptable toxicity.

ARM C: Patients receive capecitabine orally (PO) twice daily (BID) on days 1-14. Treatment repeats every 3 weeks for up to 6 courses in the absence of disease progression or unacceptable toxicity.

After completion of study treatment, patients are followed up for up to 10 years.

Details
Treatment Capecitabine, laboratory biomarker analysis, questionnaire administration, cisplatin, quality-of-life assessment, carboplatin
Clinical Study IdentifierNCT02445391
SponsorECOG-ACRIN Cancer Research Group
Last Modified on27 May 2020

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