Low-dose UVA1 Radiation in Cutaneous Lupus Patients

  • STATUS
    Recruiting
  • End date
    Sep 15, 2022
  • participants needed
    15
  • sponsor
    Ben Chong
Updated on 15 February 2021
phototherapy

Summary

The investigators are conducting an open-label clinical trial determining the effects of UVA1 phototherapy on cutaneous lupus (CLE) patients. Past research on systemic lupus (SLE) subjects indicates that this treatment is likely to be effective in treating cutaneous lupus with few side effects. The fact that most CLE patients are seen at dermatology clinics also increases the usefulness of this study because there is a large probability that phototherapy treatment will be accessible for many of the patients that stand to benefit from it.

Description

Study subjects will receive low dose (20 J/cm2) UVA1 phototherapy treatment three times per week for 10 weeks. Each treatment will take less than 30 minutes. This period will be followed by an eight-week observation phase to assess longer term effects of the treatment. Patients will be assessed for disease activity, and blood studies and photos will be completed prior to, during, and after phototherapy treatment. Optional skin biopsies of affected and unaffected skin will be performed at the beginning and end of the active treatment phase.

Details
Condition Subacute cutaneous lupus erythematosus, Cutaneous Lupus Erythematosus
Treatment UVA1 radiation treatment
Clinical Study IdentifierNCT01776190
SponsorBen Chong
Last Modified on15 February 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

You must be 18 years or older with a diagnosis of cutaneous lupus
You must have at least two active areas of cutaneous lupus
You will need to come in three days a week for a 10-week period
You will need to participate in four physician visits and blood draws

Exclusion Criteria

You do not have a diagnosis of cutaneous lupus
You have less than two active areas of cutaneous lupus
You are unable to come in three days a week for treatment for a 10-week period
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