Last updated on August 2019

Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Volume Responsiveness in Septic Shock | Intravascular Doppler | Toxic Shock Syndrome | Vein Collapsibility
  • Age: Between 18 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • patients in severe sepsis or septic shock
  • intubation and mechanical ventilation
  • sedated patient without spontaneous respiratory efforts
  • central venous catheter in place inserted via right internal jugular vein
  • signed informed consent by family members

Exclusion Criteria:

  • superior vena cava vascular anomaly
  • irradiation of neck or mediastinum in medical history
  • thrombosis of superior vena cava in medical history
  • atrial fibrillation or other irregular rhythm
  • permanent or external pacemaker
  • aggressive mechanical ventilation (PEEP above 10 cm H2O, Pmax above 30 cm H2O)
  • TOE contraindication (oesophageal varices, stricture, tumour, upper gastrointestinal bleeding)
  • Pericardial effusion, constrictive pericarditis
  • Moderate or severe valvular lesion
  • Severe systolic dysfunction of the left (EF less than 30%) or right ventricle (FAC less than 25%)
  • Intraabdominal pressure above 20 mmHg
  • Open chest
  • Obvious severe hypovolemia ( LVEDA<5.5cm2/m2BSA)

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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