Fluid Responsiveness in Septic Shock Evaluated by Caval Ultrasound Doppler Examination

  • STATUS
    Recruiting
  • days left to enroll
    12
  • participants needed
    60
  • sponsor
    Charles University, Czech Republic
Updated on 23 January 2021
sepsis
mechanical ventilation
severe sepsis

Summary

The study aims at clarification of venous collapsibility measures with real venous flow measurements during dynamic maneuver testing fluid responsiveness in septic shock patients.

Description

Sedated and mechanically ventilated patients in septic shock will be enrolled in the study. A fine catheter with ultrasound doppler probe will be introduced into the central venous catheter already in place in superior vena cava. Doppler signal will be evaluated by console prototype (NILUS Medical) and continuous analysis of blood flow velocity respiratory variation will be performed. These values will be compared to standard hemodynamic monitoring parameters (central venous and arterial pressures) and to parameters acquired by transoesophageal (TOE) and transthoracic echocardiography.

Details
Condition Toxic Shock Syndrome, Vein Collapsibility, Intravascular Doppler, Volume Responsiveness in Septic Shock, septic shock
Treatment passive leg raising
Clinical Study IdentifierNCT02676427
SponsorCharles University, Czech Republic
Last Modified on23 January 2021

Eligibility

Yes No Not Sure

Inclusion Criteria

patients in severe sepsis or septic shock
intubation and mechanical ventilation
sedated patient without spontaneous respiratory efforts
central venous catheter in place inserted via right internal jugular vein
signed informed consent by family members

Exclusion Criteria

superior vena cava vascular anomaly
irradiation of neck or mediastinum in medical history
thrombosis of superior vena cava in medical history
atrial fibrillation or other irregular rhythm
permanent or external pacemaker
aggressive mechanical ventilation (PEEP above 10 cm H2O, Pmax above 30 cm H2O)
TOE contraindication (oesophageal varices, stricture, tumour, upper gastrointestinal bleeding)
Pericardial effusion, constrictive pericarditis
Moderate or severe valvular lesion
Severe systolic dysfunction of the left (EF less than 30%) or right ventricle (FAC less than 25%)
Intraabdominal pressure above 20 mmHg
Open chest
Obvious severe hypovolemia ( LVEDA<5.5cm2/m2BSA)
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