Last updated on July 2020

Impact of a Melatonin Supplementation on the Quality of Life in Elderly Metastatic Cancer Patients

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Cancer | Cancer (Pediatric) | Neoplasms | Ewing's Family Tumors | Cancer/Tumors
  • Age: Between 70 - 100 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Age > = 70 years.
  • Performance status < = 2 (WHO criteria)
  • Life expectancy > 3months
  • A patient with solid tumor locally advanced or metastatic
  • Indication of systemic anticancer treatment : oral or IV chemotherapy, endocrine therapy, target therapy or immunotherapy
  • MMS-orientation 7 (geriatric Mini Mental State face-to-face questionnaire)
  • Able to swallow and retain oral treatment
  • Patient who signed the participation consent before entering the trial
  • Patient able to read, write and understand French.
  • Affiliation to the french social security scheme (or beneficiary of such a scheme) under the terms of the law of 9 August 2004.

Exclusion Criteria:

  • Haematological cancers
  • Renal failure or hepatic failure
  • Auto-immune disease
  • Diagnosed neurodegenerative diseases
  • Unability to fill out questionnaires
  • melatonin treatment ongoing or completed for less than 3 months
  • Treatment with an investigational drug, participation to another therapeutic clinical trial within <30 days
  • Hypersensitivity to melatonin or any of the excipients
  • Current Treatment with fluvoxamine, 5- or 8-methoxypsoralen, cimetidine, estrogen
  • A history of known or suspected excessive alcohol use.
  • Patient refusing to participate and / or unable to give informed consent
  • Patient unable to complete the questionnaires even with the help of a relative or a nurse
  • Patient does not have the capacity to comply with the study requirements
  • Patient deprived of liberty by a court or administrative.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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