Investigation of the Human Immune Response in Normal Subjects and Patients With Disorders of the Immune System and Cancer

  • STATUS
    Recruiting
  • participants needed
    1000
  • sponsor
    National Cancer Institute (NCI)
Updated on 26 April 2021
platelet count
cancer
blood transfusion
apheresis
autoimmune disorder

Summary

This protocol is being submitted to consolidate, update, and expand two previously approved protocols (77-C-0066 and 82-C-0044) into a single protocol. The purpose of this study is to examine the factors involved in the regulation of the immune system of healthy individuals and to define the abnormalities in this regulation that underlies the immunological disorders of patients with a variety of immunodeficiency and malignant disorders. The studies will include the ex vivo phenotypic and functional analysis of the network of cells involved in humoral and cellular immune responses, and in vivo testing for the capacity to make delayed-type hypersensitivity and humoral responses following immunization with a variety of antigens. Individuals to be studied will include patients with a variety of malignancies and patients with primary and secondary immunodeficiency disorders. Selected family members or family members known to be genetic carriers of certain immunodeficiency diseases as well as normal, unrelated individuals will also be studied. A small number of procedures will be used including analysis of blood obtained by phlebotomy, apheresis, skin testing and recall antigens and immunization to assess humoral immunity.

Description

Background
  • The evaluation of the cells of the immune system and HTLV-1 infection have been a central focus of the Metabolism Branch for the past 30 years.
  • Blood obtained by apheresis or blood drawing, skin biopsies and other tissues will be evaluated for abnormalities related to immunity, HTLV-1 infection and the immune system.
  • Advances in the characterization of acquired genetic changes in tumor samples has

led to insights for the development of targeted therapy of malignancy

Objectives
  • To characterize the molecular biology and immunological features as well as the clinical course of individuals with suspected or known disorders of the immune system or cancer
  • To define the nature of the immunological, genetic and epigenetic abnormalities in the cells of participants with immunodeficiency diseases associated with infections and/or a high incidence of malignancy and in participants with cancer.
  • To obtain whole blood, plasma and leukocytes, as well as skin, lymph node and bone marrow biopsies on participants with immunodeficiency or cancer to investigate the immune system.
Eligibility
  • Subjects with cancer.
  • Subjects with immunodeficiency.
  • Subjects with HTLV-1 infection.
Design

-This is a natural history study that permits tissue acquisition for analysis of the immune system and HTLV-1 infection.

Details
Condition Multiple Myeloma, Lymphoma, B-Cell Lymphoma, T-Cell Lymphoma, Non-Hodgkin's Lymphoma, Lymphoma, B-Cell, ATL, b-cell lymphomas, b cell lymphomas, b cell lymphoma, multiple myeloma (mm), t cell lymphoma
Clinical Study IdentifierNCT00001582
SponsorNational Cancer Institute (NCI)
Last Modified on26 April 2021

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