Single Session Combined Locoregional Therapies for Hepatocellular Carcinoma

  • End date
    Dec 22, 2023
  • participants needed
  • sponsor
    Sherief Abd-Elsalam
Updated on 22 January 2021
platelet count
serum bilirubin
radiofrequency ablation
hepatocellular carcinoma
unresectable hepatocellular carcinoma


Hepatocellular carcinoma is the third most common cause of cancer-related mortality. In recent years, transarterial chemoembolization, radio frequency ablation and microwave ablation have been accepted as treatment modalities for patients with surgically unresectable hepatocellular carcinoma.


To compare between combination treatment with radiofrequency or microwave ablation followed by transarterial chemoembolization and performed in a single session.

Condition HEPATIC NEOPLASM, Liver Cancer, Liver Cancer, Biliary Tract Cancer, cancer, liver, cancer, hepatic, cancer, hepatocellular, liver cancers
Treatment Transarterial chemoembolization (TACE), Radiofrequency ablation combined with TACE, Microwave ablation combined with TACE
Clinical Study IdentifierNCT02646137
SponsorSherief Abd-Elsalam
Last Modified on22 January 2021


Yes No Not Sure

Inclusion Criteria

Child classification A or B
serum albumin 3 gm/L
serum bilirubin < 2.5 mg/dL
platelet count 70,000 mm3
INR 1.6
serum creatinine < 2 mg/dl
tumor size more than 4 cm and confined to one lobe of the liver

Exclusion Criteria

Patients with portal vein thrombosis
A technically inaccessible hepatic artery
Metastatic HCC
More than three lesions
lesions in close proximity to the portal vein (PV),inferior vena cava (IVC) or gall bladder were excluded from the study
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