GnRH for Luteal Support in IVF/ICSI/FET Cycles

  • End date
    Mar 4, 2023
  • participants needed
  • sponsor
    University Reproductive Associates
Updated on 4 June 2022
gonadotrophin releasing hormone analogue
embryo transfer
intracytoplasmic sperm injection


During IVF cycles an embryo is generally placed into the uterine cavity between 3 and 5 days after fertilization. For a successful pregnancy to take place, that embryo must then implant in the properly primed and staged endometrium, which subsequently must continue to develop to accommodate the growing and maturing embryo and then fetus. This process is normally regulated by hormonal interactions between the fetal, endometrial and luteal tissue. It has been found that after IVF additional support for the endometrium with progesterone improves implantation and subsequent live birth rates in IVF cycle . Recent data has shown that additional supplementation with a single administration of a GnRH agonist around the time the time of embryo transfer may further enhance these rates .


see above

Condition Infertility
Treatment Placebo, GnRH
Clinical Study IdentifierNCT02357654
SponsorUniversity Reproductive Associates
Last Modified on4 June 2022


Yes No Not Sure

Inclusion Criteria

women undergoing IVF/ICSI or frozen embryo transfers (FET) that less than 40 years old

Exclusion Criteria

day 3 transfers
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