Last updated on August 2018

Tracking Outcomes and Practice in Pediatric Pulmonary Hypertension

Brief description of study

The TOPP-2 registry is an international, non-interventional, prospective registry including children and adolescents newly diagnosed with pulmonary hypertension (PH) to gain further insights in the disease course and long-term outcome of PH in childhood.

Patients will undergo clinical assessments and receive standard medical care, as determined by treating physicians in their daily clinical practice. The TOPP-2 registry is specifically designed to capture the variables that have been proposed as treatment goals in PePH and the reasons for changes in treatment strategy.

The TOPP-2 registry uses the new clinical classification of PH as outlined at the 5th World Symposium for Pulmonary Hypertension (WSPH) in Nice 2013 and includes new characterizations for children with PH.

The registry is planned and implemented under the scientific leadership of the Association for Pediatric Pulmonary Hypertension (PePH), independently from the financial sponsors.

At least 200 of the enrolled patients will have a follow-up period of 3 years.

Clinical Study Identifier: NCT02610660

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Stanford Children's Hospital

Palo Alto, CA United States
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Emory University

Atlanta, GA United States
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St Louis Children's Hospital

Saint Louis, MO United States
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Texas Children's Hospital

Houston, TX United States
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Primary Children's Hospital

Salt Lake City, UT United States
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Seattle Children's Hospital

Seattle, WA United States
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Recruitment Status: Open

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