Genetic and Environmental Determinants That Control Metabolism in Pulmonary Hypertension

  • STATUS
    Recruiting
  • days left to enroll
    86
  • participants needed
    20
  • sponsor
    University of Pittsburgh
Updated on 25 May 2022
iron
right heart catheterization

Summary

The investigators are performing this research study to determine whether having low iron-sulfur cluster levels can cause a disease known as pulmonary hypertension (PH). PH is defined as abnormally high blood pressure in the arteries of the lungs.

Usually, small specialized structures inside each human cell called mitochondria are in charge of generating energy within lung arteries for normal function. During situations of disease or stress, lung arteries undergo a change in the function of mitochondria, resulting in the development of PH. In studies on mice, investigators have learned that alterations in the production of specific metal complexes called iron-sulfur clusters are responsible for these changes. This makes it more likely that mice will develop PH.

In this study, the investigators want to find out if alteration of iron-sulfur cluster formation leads to increased likelihood of developing PH in humans.

Description

Test group:

The study will include two visits for the test group:

At visit one there will be required and optional research activities as the following:

Required research activities:

-Peripheral blood draw (3.5 tablespoons) drawn by research coordinator. This blood is to isolate PBMCs for generation of iPSCs.If patient did not want to give a blood sample we will ask if willing to give a urine sample. A clinical research coordinator will give the patient a plastic container and will explain how use it.

The following research activities will be optional at visit one:

  1. Physical exam and blood work (kidney/liver, blood count, coagulation, B-HCG, iron studies, and plasma for microRNA) processed at Presby Lab. This will be required if the patient approved to do right heart cath.
  2. Electrocardiogram.
  3. 6 Minute Walk Test.
  4. Skin Biopsy from underarm or inner thigh by physician (Dermatology department) (if patients agree to do, if not, we will only get a blood sample)
  5. Resting Echocardiogram

This visit will last 7-8 hours.

Study Visit Two:

This will include optional Right Heart Catheterization.

  • Right Heart catheterization by PI/Sub-Investigator. Duration ~ 3 hours
  • IF the results show that the pressure in the lung vessels is elevated without exercise AND there is no other abnormality in the heart function, we will NOT do exercise testing.
  • IF the patients are physically able to perform exercise testing/agree to do an exercise testing, patients will have an Exercise Right Heart catheterization and a Rest and Stress Echocardiography. (Determined by PI/Sub-Investigator
  • All participants who will do right heart catheterization will have to do a pregnancy test before the procedure.
  • Exercise Echocardiogram completed in. If patient unable to exercise medication (Dobutamine) will be given. Duration ~ 1-2 hours
  • Exercise Right Heart catheterization Duration ~ 2-3 hours

CONTROL GROUP

Control group will only have one visit. At this visit there will be a minimum required research activity to participate in the study and this will include:

-Peripheral blood draw (3.5 tablespoons) drawn by research coordinator. This blood is to isolate PBMCs for generation of iPSCs. If participant did not want to give a blood sample we will ask if willing to give a urine sample.

The following research activists will be optional at visit one:

  1. Physical exam and blood work (kidney/liver, blood count, coagulation, B-HCG, iron studies, and plasma for microRNA) processed at Presby Lab. This will be required if the patient approved to do right heart cath.
  2. ECG, done by research coordinator and read by PI/Sub-Investigator.
  3. 6 Minute Walk Test, done by research coordinator, if patient could perform.
  4. Skin Biopsy from underarm or inner thigh by physician (Dermatology department) (if patients agree to do, if not, we will only get a blood sample) This visit will last 6-7 hours.

Details
Condition Iron-sulfur Cluster Deficiency, Pulmonary Hypertension, Friedreich Ataxia
Treatment Blood draw, Right Heart Catheterization
Clinical Study IdentifierNCT02594917
SponsorUniversity of Pittsburgh
Last Modified on25 May 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Consenting individuals age 18-60 years of age
Have a confirmed genetic homozygous mutation (including ISCU1/2, FXN, BOLA3, NFU1) that causes the impairment of iron-sulfur cluster formation; such a subject will not be excluded from this study even if that patient's first degree relative(s) does not enroll in this pilot study
INCLUSION CRITERIA for Control Group
Consenting individuals age 18-60 years of age
First degree family member (mother, father, sister, brother, son, or daughter) of recruited individual in the test group
Have a confirmed heterozygous genetic mutation (including ISCU1/2, FXN, BOLA3, NFU1)

Exclusion Criteria

Impaired decision making capacity
Inability to consent to procedures
Children less than 18 years of age and adults older than 60 years of age
Current pregnancy
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