Effects of rTMS Based on Hemodynamic Activity for Language Recovery in Early Poststroke Aphasia

  • End date
    Dec 22, 2023
  • participants needed
  • sponsor
    Seoul National University Bundang Hospital
Updated on 7 October 2022
transcranial magnetic stimulation
nonfluent aphasia


The aim of this study is to assess the safety and clinical efficacy of repetitive transcranial magnetic stimulation (rTMS) based on hemodynamic brain activity pattern with functional near infrared spectroscopy (fNIRS) in early poststroke nonfluent aphasia patients.


Most conventional rTMS studies employed an inhibitory low frequency protocol for the contralesional homologs of Broca's area.

In the present randomized controlled trial, investigators will perform fNIRS prior to rTMS treatment to select the stimulation method. Stimulation site (perilesional or contralesional) and frequency (excitatory high or inhibitory low) will be determined by activation pattern from the fNIRS with language task in individual patients.

The patient who shows a dominant neural activity at perilesional Broca's area on fNIRS scanning will be randomly allocated into two groups: high frequency stimulation group and sham stimulation group. If a patient shows a dominant neural activity at contralesional homologs of Broca's area on fNIRS scanning, the patient will be allocated to a low frequency stimulation group.

Condition Stroke, Aphasia
Treatment MagPro magnetic stimulator (HF rTMS), MagPro magnetic stimulator (sham), MagPro magnetic stimulator (LF rTMS)
Clinical Study IdentifierNCT02591719
SponsorSeoul National University Bundang Hospital
Last Modified on7 October 2022


Yes No Not Sure

Inclusion Criteria

-80 yrs old
Radiologically confirmed left hemisphere stroke within 6 months
Fluent in Korean
First ever stroke
Non-fluent (motor-dominant) aphasia
Written informed consent

Exclusion Criteria

Previous medical histories of stroke, cerebral vascular operation
Patients with traumatic brain injury
Unable to perform the language task
Severe cognitive impairment (MMSE less than 16)
Skin lesion in the stimulation site of scalp
Metal implants in the body (cardiac pacemaker or aneurysm clip)
Pregnancy, breastfeeding
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