Last updated on February 2018

Trial of Oral Glutamine on Mitochondrial Function in CKD

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Cardiovascular Disease | Muscle Mitochondrial Function | Sarcopenia | Endothelial Dysfunction | Nephropathy
  • Age: Between 20 - 69 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Adults between 20 and 69 years of age
  • Diagnosis of moderate-severe CKD, defined in this study as an estimated glomerular filtration rate (eGFR) of 60ml/min/1.73m2 using the Chronic Kidney Disease Epidemiology Collaboration equation
  • Ability to understand and provide informed consent to participate in the study

Exclusion Criteria:

  • On chronic dialysis
  • Expectation to start dialysis within 6 months or dialysis access in place.
  • Pregnant
  • Have physical immobility (defined by wheelchair use)
  • Insulin dependent diabetes
  • Have implants incompatible with MRI
  • Exercise limiting cardiopulmonary disease (e.g. angina, severe heart valve disease, severe COPD, coronary ischemia)
  • Use of anticoagulation (i.e. warfarin)
  • Baseline systolic blood pressure >160 or diastolic blood pressure >100
  • Inflammatory conditions (e.g. autoimmune disease, HIV)
  • Thyroid disease
  • Dementia or inability to consent
  • Cirrhosis, active/chronic hepatitis
  • Use medications interfering with muscle or mitochondrial function, including steroids, anti-psychotic, Coenzyme Q-10, immunosuppresssives, antivirals, and muscle relaxants
  • Weight >300 lbs
  • Personal history or family history of deep vein thrombosis, pulmonary embolism
  • Active malignancy
  • Patients hospitalized within the past 60 days for any reason.
  • Patients with a history of a major atherosclerotic event (defined as combined incidence of myocardial infarction, urgent target-vessel revascularization, coronary bypass surgery, and stroke) within 3 months

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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