Last updated on July 2019

Fixed Dose Intervention Trial of New England Enhancing Survival in SMI Patients

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Serious Mental Illness | Bipolar Disorder | Major depression | Psychosis | Schizophrenia | Cardiovascular Disease | Endogenous depression
  • Age: Between 18 - 89 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Incident or prevalent cases: schizophrenia, schizoaffective disorder, bipolar disorder, major depressive disorder, or psychosis NOS (chart diagnosis).
  • Age 18 years and older.
  • Recent treatment with a standing 2GA, e.g., receiving a standing 2GA in the past 6 months.
  • Concomitant psychotropic medications will be allowed.
  • Ongoing treatment of their mental illnesses at one of four study mental health clinics, defined as entering one of the two-year First Episode Clinic treatment programs as a de novo patient (new disease) or having been diagnosed >2 years ago and had at least six visits in the past 12 months (prevalent disease).

Exclusion Criteria:

  • Unstable/active disease or potential contraindications with both study medications, e.g., diabetes, unstable angina or recent acute coronary syndrome, pregnancy, very high risk factors on the screening labs (e.g., A1c>7%), renal failure, liver failure, or both statin and angiotension drug contraindications.
  • Unable to provide informed consent, e.g., has dementia, developmental disability, other cognitive disorder, or fails screening mini-mental status exam (subjects with guardians may participate with guardian consent)
  • Receiving active cardiovascular treatment, defined as receiving both a statin or ARB in the past three months.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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