Last updated on February 2019

Retinoic Acid Homeostasis in Neuropsychiatric Diseases


Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Endogenous depression | Schizophrenia | Major depression | Alzheimer's Disease | Alcohol abuse
  • Age: Between 18 - 65 Years
  • Gender: Male or Female

MDD-Group

Inclusion Criteria:

  • depressive episode in the context of unipolar major depression
  • at least 18 points or more on the BDI and HAMD-17

Exclusion Criteria:

  • additional or comorbid axis-I or axis-II disorder
  • current history of any neurological or other serious medical condition
  • any psychopharmacological treatment or substance use within the last two weeks or 5 half-lives (whichever is longer) of the respective substance
  • any oral or topical application of retinoid-containing preparations within the last 3 months

AD-Group

Inclusion Criteria:

  • diagnosed AD

Exclusion Criteria:

  • any other neurodegenerative disorder
  • any oral or topical application of retinoid-containing preparations within the last 3 months

Schizophrenia-Group

Inclusion Criteria:

  • subjects with schizophrenia
  • intended therapy with clozapine, olanzapine or aripiprazole
  • BMI: 18 - 29,9 kg/m2

Exclusion Criteria:

  • presence of diabetes or pathological glucose tolerance
  • presence of and chronic inflammatory disease
  • any psychopharmacological treatment of clozapine, olanzapine or aripiprazole within the last 3 months
  • any oral or topical application of retinoid-containing preparations within the last 3 months

Alcoholism-Group

Inclusion Criteria:

  • subjects with alcoholism who either still consume alcohol or are abstinent for at least 4 weeks

Exclusion Criteria:

  • any oral or topical application of retinoid-containing preparations within the last 3 months
  • current history of any neurological or other serious medical condition despite liver diseases

Recruitment Status: Open


Brief Description Eligibility Contact Research Team


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