In Vivo and ex Vivo Validation of MR Tractography of Brain White Matter Tracts - FIBRATLAS II-III

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  • participants needed
  • sponsor
    University Hospital, Tours
Updated on 12 June 2021
Christophe DESTRIEUX, PhD
Primary Contact
University Hospital of Angers (0.7 mi away) Contact
+6 other location


White matter tracts connect cortical areas to other parts of the cortex, to basal ganglia and to the brain stem and spinal cord. These tracts form the internal part of the brain and transmit the nervous impulses. Changes in brain white matter may serve as biomarkers for numerous neurological diseases.

Diffusion Weighted Imaging (DWI) is a non-invasive MRI (Magnetic Resonance Imaging) technique providing information on white matter tracts (tractography) by studying water diffusion. Since it is based on complex mathematical models that only indirectly evaluates the underlying anatomy, tractography need to be validated before being used for research and clinical purposes. Several validation techniques were previously proposed, none of them being fully convincing in human.

Condition Neurological Diseases
Treatment MRI
Clinical Study IdentifierNCT02455284
SponsorUniversity Hospital, Tours
Last Modified on12 June 2021


Yes No Not Sure

Inclusion Criteria

Prior enrollment in a body donation program
Age 82 years
Absence of major cognitive impairment as demonstrated by independent living skills in 4 fields evaluated by the IADL (4 items) (Lawton and Brody, 1969)
Distance to one of the participating laboratories 120km
Able to remain supine in the MR scanner for acquisition duration (60 min)
Affiliation to Social Security
Informed and written consent
Non Inclusion Criteria
Past or present Neurological or Neurosurgical diseases (excluding trauma or degenerative spinal lesions)
Uncontrolled: High blood pressure, diabetes (types I or II), or dyslipemia
Contraindications to MRI
Contraindication to body donation

Exclusion Criteria

Diagnosis on MRI of brain lesions, excepted common age-related changes
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