Last updated on February 2020

Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: childhood ALL | Lymphocytic Leukemia | Acute
  • Age: Between 1 - 50 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Age at diagnosis at 1 to 50 years.
  • The start of induction therapy within a time interval of study recruitment phase.
  • The diagnosis of ALL is to be proved by the morphological, cytochemical, and immunological analysis of tumor cells in bone marrow (see "Diagnostics"). Patients with B-cell (Burkitt) ALL are excluded.
  • Informed consent of the patient parents (guardians) to be treated in one of the clinics included in this multicenter study.

Exclusion Criteria:

  • ALL is a second malignancies;
  • The disease is a relapse of previously misdiagnosed and, therefore, inadequately treated ALL;
  • There is severe concomitant disease, which significantly impedes chemotherapy protocol (such as multiple malformations, heart diseases, metabolic disorders, etc.);
  • There is a lack of important data needed for the exact adherence to the cytostatic therapy according to a specific chemotherapy protocol (differential diagnosis of ALL-AML (acute myeloid leukemia) is not possible, stratification according to therapeutic group is not possible);
  • The patient was treated before for a long time with cytotoxic drugs;
  • There were treatment deviations not covered by the protocol and/or not due to side effects of treatment and/or complications of the disease

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

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