Last updated on February 2018

Childhood Acute Lymphoblastic Leukemia Treatment Protocol Moscow-Berlin 2015 (ALL-MB 2015)


Brief description of study

QUESTIONS AND OBJECTIVES OF ALL-MB 2015 STUDY

  1. Will the new risk group stratification (especially of T-ALL) to improve overall and event-free survival?
  2. Will the new protocol is effective and feasible in patients older than 15 years, and especially in young adults?
  3. Whether the intermittent dexamethasone administration in induction will result in a decrease in toxicity and mortality without loss of efficacy?
  4. Whether the methylprednisolone administration as basic glucocorticoids during induction, consolidation and maintenance therapy will lead to decrease of severe infections and early mortality rate, improve survival and therapy compliance in adolescents and young adults with B-precursor ALL?
  5. Whether the administration of Bortezomib in patients with B-precursor ALL with initial WBC100,000/l will improve treatment outcome?
  6. Whether the administration of Idarubicin instead Daunorubicin in low-risk T-ALL patients and two-phase induction in intermediate-risk T-ALL patients will reduce relapse rate and improve survival?

Clinical Study Identifier: NCT03390387

Find a site near you

Start Over

Amur Regional Clinical Children's Hospital

Blagoveshchensk, Russian Federation
  Connect »

Regional Children's Hospital

Lipetsk, Russian Federation
  Connect »

Regional Clinical Children's Hospital

Nizhny Novgorod, Russian Federation
  Connect »

Regional Clinical Children's Hospital

Rostov-on-Don, Russian Federation
  Connect »

Rostov Research Institute of Oncology

Rostov-on-Don, Russian Federation
  Connect »

Almazov National Medical Research Center

Saint Petersburg, Russian Federation
  Connect »

Children's Municipal Hospital N1

Saint Petersburg, Russian Federation
  Connect »

Municipal Clinical Hospital N31

Saint Petersburg, Russian Federation
  Connect »