Minocycline Attenuate Postoperative Cognitive Dysfunction and Delirium

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    RenJi Hospital
Updated on 23 January 2021


Postoperative cognitive dysfunction (POCD) and postoperative delirium occurs mainly in aged patients. POCD and POD may increase the mortality and morbidity. However, the mechanism of POCD is not clear yet and no effective therapy method was proved. According to previous study, the neuroinflammation is the main reason both for POCD and POD. Minocycline is a tetracycline derivative. Due to it's lipophilic structure, it is easy to pass through blood brain barrier and attenuate neuroinflammation. It's neuroprotective effects has been proven in many experimental animal models such as Alzheimer's disease, Huntington's disease and Parkinson's syndrome. In present study, the investigators hypothesized that minocycline would attenuate the incidence of POCD and POD in the aged patients.

Condition Malignant neoplasm of prostate, Colorectal Cancer, Malignant neoplasm of kidney, Rectal Cancer, Prostatic disorder, Malignant neoplasm of colon, Renal Cell Carcinoma, Prostate Disorders, Colon Cancer Screening, Prostate Cancer, Early, Recurrent, Colon cancer; rectal cancer, Kidney Cancer, Colon Cancer, Prostate Cancer, Renal Cell Cancer, Renal Cancer, prostate carcinoma, colon carcinoma, prostate cancers, rectal carcinoma
Treatment Placebo, Minocycline
Clinical Study IdentifierNCT02928692
SponsorRenJi Hospital
Last Modified on23 January 2021


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Inclusion Criteria

Elder than 65 years old
Speak Chinese Mandarin
Signed the inform consent
No major disease health people

Exclusion Criteria

Existing cerebral disease, or have a history of neurological and psychiatric diseases including Alzheimer Disease, stroke, epilepsy and psychosis
Existing cognitive impairment as evidenced by Mini-Mental State Examination scores below 24
Severe audition or vision disorder
Unwillingness to comply with the protocol or procedures
Cannot communicated with Chinese Mandarin
Drug abuse, alcoholism
Serious heart or liver or renal insufficiency patients
Had surgery in the past 30 days
Plan to undergo surgery in the following 3 months
Clear my responses

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