A Molecular Anatomic Imaging Analysis of Tau in Progressive Supranuclear Palsy

  • End date
    Nov 15, 2025
  • participants needed
  • sponsor
    Mayo Clinic
Updated on 25 January 2022
cognitive assessment
Accepts healthy volunteers


This study is designed to learn more about overall tau burden in the brain of patients with Progressive Supranuclear Palsy (PSP).

Condition Progressive Supranuclear Palsy
Treatment F-18 AV 1451
Clinical Study IdentifierNCT02605785
SponsorMayo Clinic
Last Modified on25 January 2022


Yes No Not Sure

Inclusion Criteria

Must be over 35 years of age and present with gradual progression of PSP-related symtoms
Must have an informant or study partner that can provide independent information of functioning
Must meet criteria for possible or probable Progressive Supranuclear Palsy. To fulfill criteria for possible PSP, subjects must have a gradually progressive disorder with either vertical (upward or downward) supranuclear palsy or both slowing of vertical saccades and prominent postural instability with falls in the first year of disease onset. To fulfill criteria for probable PSP, subjects must have vertical (upward or downward gaze) supranuclear palsy and prominent postural instability with falls in the first year of disease onset

Exclusion Criteria

Subjects will be excluded if they meet criteria for another neurodegenerative disease (including corticobasal syndrome, frontotemporal dementia, primary progressive aphasia, Alzheimer's disease, multiple system atrophy and Parkinson's disease) or do not have the symptoms necessary to fulfill inclusion criteria for possible PSP
Subjects will be excluded from the study if they have any of the following genetic conditions which can increase the chance of cancer: Cowden disease, Lynch syndrome, hypogammaglobulinemia, Wiskott-Aldrich syndrome, and Down's syndrome
Subjects with concurrent illnesses that could account for their symptoms, such as traumatic brain injury, encephalitis, strokes or developmental syndromes will be excluded
Women that are pregnant or post-partum and breast-feeding will be excluded
Subjects will also be excluded if MRI is contraindicated (metal in head, cardiac pace maker, e.t.c.), if there is severe claustrophobia, if there are conditions that may confound brain imaging studies (e.g. structural abnormalities, including subdural hematoma, intracranial neoplasm or large cortical infarcts), or if they are medically unstable or are on medications that might affect brain structure or metabolism (e.g. chemotherapy)
Subjects will also be excluded if they do not have an informant, or do not consent to research
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If you are confirmed eligible after full screening, you will be required to understand and sign the informed consent if you decide to enroll in the study. Once enrolled you may be asked to make scheduled visits over a period of time.

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Complete your scheduled study participation activities and then you are done. You may receive summary of study results if provided by the sponsor.

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