Last updated on June 2020

Determination of the Optimal Dose of Ephedrine in Intraoperative Arterial Hypotension of Newborns and Infants up to 6 Months of Age.

Are you eligible to participate in this study?

You may be eligible for this study if you meet the following criteria:

  • Conditions: Intraoperative Arterial Hypotension | Neonate
  • Age: - 1 Years
  • Gender: Male or Female

Inclusion Criteria:

  • Newborns or infants < 6 months of age,
  • boys and girls,
  • premature or not,
  • requiring general anesthesia induced by sevoflurane
  • who presents during anesthesia a decrease of blood pressure superior to 20% of the basal mBP (measured prior to surgery) despite of vascular filling with sodium chloride 0.9% (10mL/kg during 10 min).
  • Written, informed consent obtained from the 2 parents

Exclusion Criteria:

  • Allergy to Ephedrine.
  • Emergency surgery.
  • Patient having previously received other vasopressive amines.
  • Use of other indirect sympathomimetic drug such as phenylpropanolamine, phenylephrine, pseudoephedrine and methylphenidate.
  • Premedication with clonidine
  • Congenital heart disease
  • IV-induced anesthesia.

Recruitment Status: Open

Brief Description Eligibility Contact Research Team

Volunteer Sign-up

Sign up for our FREE service to receive email notifications when clinical trials are posted in the medical category of interest to you.