Treatment for Calcium Phosphate Kidney Stone Disease

  • STATUS
    Recruiting
  • End date
    Jul 22, 2023
  • participants needed
    50
  • sponsor
    University of Texas Southwestern Medical Center
Updated on 22 March 2022

Summary

The investigators will examine in two studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of Calcium Phosphate stone formers.

Description

We will examine in two short-term placebo-controlled cross-over metabolic studies whether citric acid or potassium citrate can reduce calcium phosphate saturation in urine of CaP stone formers. The first study will be conducted in hypocitraturic CaP stone formers without hypercalciuria, and will compare the effects of potassium citrate, citric acid and placebo.

The second study will be conducted in hypercalciuric CaP stone formers on a thiazide diuretic who require potassium supplementation, and will compare the effects of potassium chloride alone, potassium chloride + citric acid, and potassium citrate alone. Physicochemical assays will be applied in addition to computer-based stone risk prediction programs to assess risk of stone recurrence.

Details
Condition Calcium Phosphate Kidney Stones
Treatment Placebo, potassium citrate, Citric Acid, Citric Acid, Indapamide, Indapamide
Clinical Study IdentifierNCT01754779
SponsorUniversity of Texas Southwestern Medical Center
Last Modified on22 March 2022

Eligibility

Yes No Not Sure

Inclusion Criteria

Aim 1
Hypocitraturic CaP stone formers
urine citrate <320mg/d
elevated pH as 24-hr urine pH above 6.40
>21 years
Aim 2
Hypercalciuric CaP stone formers
hr urine calcium >250mg/d in women and >300mg/d in men prior to indapamide use
high pH as >6.40 in the absence of urinary tract infection
>21 years
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