The Effect of Methylphenidate Treatment in Familial Attention Deficit/Hyperactivity Disorder (ADHD)

  • End date
    Dec 25, 2023
  • participants needed
  • sponsor
    Sheba Medical Center
Updated on 25 May 2022


The purpose of this study is to investigate the familial response to Methylphenidate treatment (Ritalin IR) in two aspects: ADHD symptom's improvement and side-effects development.


Attention Deficit/Hyperactivity Disorder (ADHD) is very prevalent and tends to continue from childhood to adult life. It's heritability is 76%. It was found that there is a greater ADHD prevalence in first-degree families of ADHD subjects- 4-6 times more than the general population.

Pharmacological treatment is the first line treatment today in ADHD, in children and adults, and Methylphenidate (specially Ritalin IR) is the first medication given for the disorder.

The study includes couples of first-degree family members, both diagnosed with ADHD. Subjects will receive Ritalin IR for 4 weeks and undergo several psychiatric and cognitive questionnaires at each time of the follow-up meeting (a total of 3).

Condition Attention Deficit/Hyperactivity Disorder Combined Type, ADHD Predominantly Inattentive Type, ADHD Predominantly Hyperactivity Type, ADHD-not Other Specified
Treatment Methylphenidate- Ritalin IR (Immediate Release)
Clinical Study IdentifierNCT01554046
SponsorSheba Medical Center
Last Modified on25 May 2022


Yes No Not Sure

Inclusion Criteria

couples of first-degree family members, both diagnosed with ADHD (any type or ADHD-NOS) and need medical treatment

Exclusion Criteria

subjects who receive other psychiatric medications: antipsychotic medications, antidepressants medications, anti-anxiety medications or mood stabilizers
people who suffer from psychotic disorder, bipolar disorder or other severe psychiatric disorders which are not stabilized
Alcohol/drugs addicted
people with chronic neurologic diseases
people with Autism or mental retardation
people with congenital heart defect
people with hypertension/tachycardia (>100 bpm)
pregnancy or breast feed women
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